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- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 8. Using social media big data to understand the genetic and environmental aetiology of mental health and disorder in emerging adulthood
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 25. Calcium channel trafficking, nociceptive neurotransmission and mechanism of action of gabapentinoid drugs in mouse models of neuropathic pain
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 27. Forming a sensory map: the role of auditory and visual cues in the hippocampal representation of space
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
- 30. Shared Control Wheelchair Interfaces
- 32. Understanding the neurobiological effects of clinical photochemical internalisation in order to minimise nerve damage during treatment of cancer
- 33. Shedding light on the ethnic attainment gap: The influence of intercultural relations on students’ learning and performance
- 34. Patient-focused development of a versatile, wearable neurostimulation device to control urinary incontinence.
- 35. The development and evaluation of positive psychology outcome measures for people with dementia
- 36. Rehabilitation strategies to improve balance and prevent falls in people with Charcot-Marie-Tooth disease
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5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
Supervisor Pair: Dr Jude Oben and Professor Tessa Crompton
Potential Student’s Home Department: Institute for Liver & Digestive Health
Obesity induced liver disease, non-alcoholic fatty liver disease (NAFLD), is now the commonest cause of chronic liver disease in affluent nations, including the UK. The initiating defect in NAFLD is obesity related insulin resistance, with an ensuing spectrum of hepatosteatosis-steatohepatitis-cirrhosis and hepatocellular cancer. There are no proven treatments for NAFLD and understanding its pathogenesis is therefore an imperative. Obesity amongst women of reproductive age follows the general population trend with about 29% of women, aged 20-39 years, in the UK reported to be obese and this proportion continues to rise. The increasing prevalence of obesity and NAFLD may be partially explained by the increasing availability of inexpensive energy-dense foods. Excitingly, murine data from our group suggests that maternal obesity may influence offspring liver phenotype through unknown mechanisms but see: eg Mouralidarane ……., Oben JA (2013), Maternal obesity programs offspring non-alcoholic fatty liver disease via innate immune dysfunction in mice. Hepatology, 2013 Jan 12. [Epub ahead of print] and Oben et al (2010), Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol. 52:913-20.
Our aim here is to build on our success and further study the role of immune mechanisms in developmentally programmed NAFLD our pathophysiologically relevant murine model in which we will wean offspring of obese dams weaned onto an obesogenic diet, to determine if they develop a more robust dysmetabolic and NAFLD phenotype, compared to offspring of lean dams weaned onto the same obesogenic diet or a standard, control diet. Outcome measures of NAFLD will include plasma concentrations of leptin, alanine transaminase, interleukin-6, 12 and 18 and tumour necrosis factor (TNF)-α, plus hepatic triglycerides and histological evidence of hepatic steatosis. We will further determine evidence of induction of pro-fibrotic pathways in association with histological evidence for hepatic fibrogenesis. Mechanistic studies will assay the functions of key components of the hepatic innate immune system including NK-T cells and Kupffer cells. Alterations in the functions of components of the adaptive immune system in the pathogenesis of developmentally programmed NAFLD will also be investigated.
of our work is evidenced by the fact that Dr Oben has recently been
invited to join the All Party Parliamentary Group on Obesity with an
inaugural meeting at the House of Commons
in April ’13.
Please direct enquiries to Dr Oben.