SLMS Academic Careers Office

Grand Challenges

37.  Monogenic human pain disorders: gene identification and characterization using mouse models 

Supervisor Pair: Professor John N Wood and Dr James J Cox 
Potential Student's Home Department: Wolfson lnstitute for Biomedical Research, Department of Experimental Medicine 
The principal aim of this project is to identify novel pathogenic mutations in patients with heritable pain disorders and then to understand the function of the genes using cell-based assays and mouse models. We have a bank of families with heritable pain disorders that can be mapped when manpower is available. Some of these have deficits in specific pain types (e.9. cold sensitivity) that may be particularly interesting in terms of understanding pain pathways. The long term aim of this work is to identify and understand new pain targets that may lead to analgesic drug development.