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- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 8. Using social media big data to understand the genetic and environmental aetiology of mental health and disorder in emerging adulthood
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 25. Calcium channel trafficking, nociceptive neurotransmission and mechanism of action of gabapentinoid drugs in mouse models of neuropathic pain
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 22. Understanding the molecular mechanisms of pancreatic cancer progression
- 27. Forming a sensory map: the role of auditory and visual cues in the hippocampal representation of space
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
- 30. Shared Control Wheelchair Interfaces
- 32. Understanding the neurobiological effects of clinical photochemical internalisation in order to minimise nerve damage during treatment of cancer
- 33. Shedding light on the ethnic attainment gap: The influence of intercultural relations on students’ learning and performance
- 34. Patient-focused development of a versatile, wearable neurostimulation device to control urinary incontinence.
- 35. The development and evaluation of positive psychology outcome measures for people with dementia
- 36. Rehabilitation strategies to improve balance and prevent falls in people with Charcot-Marie-Tooth disease
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Supervisor Pair: Glen Jeffrey and Kenneth Smith
Potential Student’s Home Department: Institute of Opthalmology
Inflammation is an umbrella feature of ageing and a wide spectrum of eye diseases. Commonly it is associated with reduced mitochondrial function, where ATP output declines and reactive oxygen species (ROS) increases. These changes form the basis of many theories of ageing.
Ageing and disease progression are related to metabolic demand, and the retina has the greatest demand in the body, with significant age related inflammation and cell loss that can tip over into diseases such as age related macular degeneration (AMD). The retina is also the only part of the CNS that can be viewed directly in vivo, and it is possible to see the impact of ageing directly here.
The aims of this project will be to image the living retina with state of the art technology present at the Institute of Ophthalmology (IOO) that will allow us to assess inflammation and changes in mitochondrial function with molecular technologies developed at the Department of Neuroinflammation at UCL’s Institute of Neurology (ION). Currently the IOO is a world leader in retinal imaging technology and the ION has cutting edge techniques that can be employed in the eye, providing unique opportunities to address major questions in ageing and disease.
Once we have established these techniques we will use novel techniques to moderate mitochondrial function in order to increase ATP production and reducing ROS output, with the aim of combating age related changes and disease progression.