SLMS Academic Careers Office
- Clinical Academic Training
- Biomedical Academic Training
- Grand Challenges
- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 8. Using social media big data to understand the genetic and environmental aetiology of mental health and disorder in emerging adulthood
- 9. Quantifying the potential impact of mobile health (M-Health) technologies on TB control in the EU
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 21. Analysis of the performance of novel cardiac valve prosthesis: from standard experimental tests to patient-specific computational analyses
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 25. Calcium channel trafficking, nociceptive neurotransmission and mechanism of action of gabapentinoid drugs in mouse models of neuropathic pain
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 22. Understanding the molecular mechanisms of pancreatic cancer progression
- 27. Forming a sensory map: the role of auditory and visual cues in the hippocampal representation of space
- 28. Functional effects of regulatory T cells on macrophage inflammatory responses to Streptococcus pneumoniae
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
- 30. Shared Control Wheelchair Interfaces
- 32. Understanding the neurobiological effects of clinical photochemical internalisation in order to minimise nerve damage during treatment of cancer
- 33. Shedding light on the ethnic attainment gap: The influence of intercultural relations on students’ learning and performance
- 34. Patient-focused development of a versatile, wearable neurostimulation device to control urinary incontinence.
- 35. The development and evaluation of positive psychology outcome measures for people with dementia
- 36. Rehabilitation strategies to improve balance and prevent falls in people with Charcot-Marie-Tooth disease
- 37. Monogenic human pain disorders: gene identification and characterization using mouse models
- What Students Say
- Current Student Projects
- Project Call 2014
- Sensory Systems and Therapies
- Sensory Systems and Therapies / IBME DPT
- Phd Programmes
- Graduate Funding
- ACO Features
Supervisor Pair: Professor Annette Dolphin and Professor John Wood
Potential Student’s Home Department: Neuroscience, Physiology and Pharmacology
Chronic neuropathic pain results from damage to the peripheral somatosensory dorsal root ganglion (DRG) neurons One of the genes whose expression is up-regulated and is involved in the development of neuropathic pain is Cacna2d1, encoding the auxiliary calcium channel subunit α2δ-1, which is important for calcium channel trafficking. N-type calcium channels (molecular name CaV2.2) are the main calcium channel isoform involved in synaptic transmission in DRG neurons. We will investigate the hypothesis that the trafficking of CaV2.2 to presynaptic terminals is altered by the up-regulation of α2δ-1 that occurs following the development of neuropathic pain. This project will examine CaV2.2 trafficking using CaV2.2 constructs which we have engineered to have a tag in an extracellular loop. Experiments will be performed both in vitro and in vivo.
The primary supervisor, Professor Annette Dolphin is an expert in voltage gated calcium channels, in terms of their trafficking, function and interaction with other proteins. She also has a strong interest in how these channels contribute to experimental models of neuropathic pain, and has published extensively on this.
Professor John Wood is one of the acknowledged world experts in dissecting the molecular mechanisms involved in nociception by the use of mice in which specific ion channels, particularly voltage-gated sodium channels, have been knocked out in particular subsets of DRG neurons. He is also an expert in behavioural assessment of nociception, using a variety of neuropathic pain models.
The student will therefore have access to all the behavioural and mouse model expertise in John Wood’s lab, and the biochemical, imaging and electrophysiological expertise relating to understanding calcium channel function in Annette Dolphin’s laboratory.