SLMS Academic Careers Office
- Clinical Academic Training
- Biomedical Academic Training
- Grand Challenges
- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 8. Using social media big data to understand the genetic and environmental aetiology of mental health and disorder in emerging adulthood
- 9. Quantifying the potential impact of mobile health (M-Health) technologies on TB control in the EU
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 21. Analysis of the performance of novel cardiac valve prosthesis: from standard experimental tests to patient-specific computational analyses
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 25. Calcium channel trafficking, nociceptive neurotransmission and mechanism of action of gabapentinoid drugs in mouse models of neuropathic pain
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 22. Understanding the molecular mechanisms of pancreatic cancer progression
- 27. Forming a sensory map: the role of auditory and visual cues in the hippocampal representation of space
- 28. Functional effects of regulatory T cells on macrophage inflammatory responses to Streptococcus pneumoniae
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
- 30. Shared Control Wheelchair Interfaces
- 32. Understanding the neurobiological effects of clinical photochemical internalisation in order to minimise nerve damage during treatment of cancer
- 33. Shedding light on the ethnic attainment gap: The influence of intercultural relations on students’ learning and performance
- 34. Patient-focused development of a versatile, wearable neurostimulation device to control urinary incontinence.
- 35. The development and evaluation of positive psychology outcome measures for people with dementia
- 36. Rehabilitation strategies to improve balance and prevent falls in people with Charcot-Marie-Tooth disease
- 37. Monogenic human pain disorders: gene identification and characterization using mouse models
- What Students Say
- Current Student Projects
- Project Call 2014
- Sensory Systems and Therapies
- Sensory Systems and Therapies / IBME DPT
- Phd Programmes
- Graduate Funding
- ACO Features
22. Understanding the molecular mechanisms of pancreatic cancer progression
Supervisor Pair: Dr John Timms and Dr Stephen Pereira
Potential Student’s Home Department: Institute for Women’s Health, Women’s Cancer
Pancreatic cancer is a devastating disease that is most often diagnosed late, when curative therapies are no longer possible. New treatment strategies for advanced pancreatic cancer, as well as improved diagnostic and treatment options for precursor lesions and early pancreatic malignancies are urgently needed. Precursor lesions include intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs) and pancreatic intraepithelial neoplasms (PanINs). The mechanisms by which these precursor lesions progress to malignancy is poorly understood.
The aim of this project is to understand the molecular and cellular mechanisms that drive the oncogenic transformation of pancreatic cancer. Model cell lines will be developed from immortalised pancreatic ductal epithelial cells or precursor cell lines that overexpress frequently mutated oncogenic variants (KRas, GNAS) or reduced expression of tumour suppressor genes (p53, CDKN2A). The proliferation, survival and invasion of derived cell lines will be characterised using cell-based assays. Established proteomics-based profiling using in vivo metabolic labelling with SILAC will be used to examine global protein changes in response to oncogenic activation or tumour suppressor loss and these mapped to cellular phenotype to understand the molecular events associated with malignant progression. Commonly identified changes will be confirmed and promising candidates further tested in clinical and pre-clinical serum samples to establish their potential as biomarkers for the early detection of pancreatic cancer.
The project brings together expertise in cancer cell signalling and proteomics on UCL’s Bloomsbury campus with expertise in pancreatic cancer biology and diagnosis on the Royal Free campus. The two supervisors have a history of successful collaboration in the field of pancreaticobilliary disease, in particular, cancer biomarker discovery and validation. The partnerships will allow access to state of the art proteomics instrumentation, optimised proteomics workflows and established cancer cell biology techniques which will complement a substantial research programme in the area of pancreatic cancer detection and therapeutic intervention.