SLMS Academic Careers Office
- Clinical Academic Training
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- Grand Challenges
- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
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15. Ageing of the liver and protection from injury: from flies to mice to humans
Supervisor Pair: Professor Linda Partridge and Dr Manlio Vinciguerra
Potential Student’s Home Department: Division of Medicine – Institute for Liver and Digestive Health
The liver is capable of massive natural regeneration, which is impaired during ageing. The commonest liver disease, affecting 30% of the population, is non-alcoholic fatty liver disease (NAFLD), characterized by an intrahepatic accumulation of lipids. NAFLD can evolve into liver cancer in the presence of inflammation. Old age seems to favour liver diseases. However, the incidence of NAFLD and liver cancer drops significantly in individuals aged more than 75, for obscure reasons (Sheedfar F et al. Aging Cell 2013). Nutrient-sensing mechanisms implicated in ageing and liver metabolism include insulin/IGF-1/mTOR/AKT/AMPK (Lopez-Otin C et al. Cell 2013), evolutionarily conserved from the invertebrate fly Drosophila melanogaster, where liver functions are performed by the “fat body” and by cells called oenocytes (Gutierrez E et al. Nature 2007; Geminard C et al. Cell Metab 2009), to mice, whose liver physiology recapitulates the human.
The aim of this PhD Grand Challenge Studentship, at the crossroad between cell biology and pre-clinical medicine, is to study the interplay between liver injury, induced by a diet rich in fat or by genetic manipulations, and the age of the organism. As an added value the student will acquire the skills on how to model liver diseases both in the fly and in the mouse. A major focus will be on the nutrient-sensing signalling pathways involved, using transcriptomic, imaging and cell biology approaches.