SLMS Academic Careers Office
- Clinical Academic Training
- Biomedical Academic Training
- Grand Challenges
- 1. Bayesian Modelling of Disease Progression In juvenile dermatomyositis (JDM)
- 2. Mind-body interactions influencing the outcome of treatment for epilepsy
- 3. Treating retinal inflammation: bridging the divide between common problems in the eye and the brain
- 4. Development of a Novel In Vivo Animal Model for Schizophrenia Drug Testing
- 5. Immune mechanisms in Developmental Programming of Non-Alchoholic Fatty Liver Disease
- 10. Molecular Control of Pain Processing
- 11. Understanding the mechanisms of insulin secretion in patients with HADH mutations
- 12. Origins of cortico-subthalamic “hyperdirect” pathway in the motor cortex: electrophysiology and imaging
- 13. The mechanical control of tissue regeneration.
- 14. Investigating community severance in Southend and its effects on health and access to healthcare
- 15. Ageing of the liver and protection from injury: from flies to mice to humans
- 16. Intelligent nanomaterials against antibiotic resistant bacteria
- 17. Retroviral restriction factors that control species-specific gene regulation and stem cell fate
- 18. Improving women’s choice and uptake of effective contraceptive methods through development of interactive digital interventions
- 19. From embryonic cell to neuron: understanding the complexity of developmental decisions
- 20. Identification of mitochondrial biomarkers and therapeutic targets in pancreatic cancer
- 23. Television subtitling for deaf and hearing-impaired viewers: a route to improve English language skills for UK migrants with normal hearing
- 24. Large-scale phylogenomic mapping of domain architecture changes to elucidate gene function evolution
- 26. Real-time and nanometre-scale visualisation of membrane perforation in pathogen attack and immune response
- 27. Forming a sensory map: the role of auditory and visual cues in the hippocampal representation of space
- 29. Human amniotic fluid-derived induced pluripotent stem cells for the treatment of osteogenesis imperfecta.
- 31. Understanding the immunopathogenesis of juvenile-onset SLE: could targeting lipid biosynthesis control disease progression and reduce cardiovascular risk?
- 33. Shedding light on the ethnic attainment gap: The influence of intercultural relations on students’ learning and performance
- 35. The development and evaluation of positive psychology outcome measures for people with dementia
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13. The mechanical control of tissue regeneration.
Supervisor Pair: Dr Yanlan Mao and Dr Rebecca Shipley
Potential Student’s Home Department: MRC-LMCB
Tissue repair and regeneration after wounding is a fundamental problem of vast medical importance. Previous studies have largely focused on the biochemical and genetic control of tissue regeneration. However, there is increasing evidence that the mechanical environment of the tissue also plays a role in the regeneration process. The project will use an exciting interdisciplinary approach to understand how tissue mechanics contributes to regeneration, and importantly, how the tissue senses when to stop healing - a problem that has been largely neglected to-date. This will be achieved through a unique combination of live imaging, in vivo Drosophila genetics, biophysical force measurements and computational modelling, to both better understand and quantify mechanical tissue regeneration mechanisms.