Radiochemistry

Radiochemistry facilities at UCL ensure researchers have timely access to equipment, resources and expertise necessary to undertake world-leading research.

About the STP

The Centre for Radiopharmaceutical Chemistry (CRC) is a multidisciplinary research centre for the development and clinical translation of novel biomedical imaging agents. The centre has research facilities for high level radioactive labelling chemistry, tissue imaging, as well as a Good Manufacturing Practice (GMP) facility. We produce and distribute PET radiopharmaceuticals for observational studies and clinical trials across the country. Our aim is to address major health challenges by offering innovative imaging solutions.

Facility

Centre for Radiopharmaceutical Chemistry (CRC)

Location

Kathleen Lonsdale Building, 5 Gower Place, London WC1E 6BS

Contact

Director: Erik Årstad
PET Pharmacology group lead: Kerstin Sander
GMP quality manager: Ramla O. Awais

Bookings

Contact gmporders@ucl.ac.uk

Collaborations

The Centre for Advanced Biomedical Imaging (CABI)
Institute of Neurology (IoN)
Cardiovascular Sciences
The Centre for Medical Imaging (CMI)
UCL Hospital Institute of Nuclear Medicine (INM)
Royal Free NHS Trust Nuclear Medicine
Kings College London
Imperial College London
Cambridge University

Selected publications

Cousins O, Schubert JJ, Chandra A, Veronese M, Valkimadi P, Creese B, Khan Z, Arathimos R, Hampshire A, Rosenzweig I, Ballard C, Corbett A, Aasland D, Velayudhan L, O'Neill M, Collier D, Awais R, Sander K, Årstad E, Howes O, Turkheimer F, Hodges A, Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge. J Neuroinfamm. 2023; 20:272.1-13.
Sirindil F, Maher S, Schöll M, Sander K, Årstad E. Oxidation-Cyclisation of Biphenyl Thioethers to Dibenzothiophenium Salts for Ultrarapid 18F-Labelling of PET Tracers. Int J Mol Sci. 2022; 23(24):15481.
Yap SY, Frias B, Wren MC, Schöll M, Fox NC, Årstad E, Lashley T, Sander K. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain. 2021;144(8):2284-2290. doi: 10.1093/brain/awab120. P
Sander K, Gendron T, Cybulska KA, Sirindil F, Zhou J, Kalber TL, Lythgoe MF, Kurzawinski TR, Brown MJ, Williams B, Årstad E. Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism. J Med Chem. 2021 Jul 8;64(13):9321-9329.
Gendron T, Sander K, Cybulska K, Benhamou L, Sin PKB, Khan A, Wood M, Porter MJ, Årstad E. Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination. J Am Chem Soc. 2018 Sep 5;140(35):11125-11132.