This page provides a portal to all of UCL's world-class Mass Spectrometry facilities.
UCL/Birkbeck ISMB Mass Spectrometry group studies the structure and dynamics of proteins and protein complexes using a combination of structural mass spectrometry approaches such as native, ion mobility and crosslinking. Computational tools are also developed to process the data obtained. Research projects involve developing methods for the study of flexible proteins, the study of protein complexes of type IV secretion systems, protein misfolding diseases such as alpha-1 antitrypsin. For further information contact Dr Kostas Thalassinos.The School of Pharmacy Mass Spectrometry facility offers state-of-the-art instruments including two tandem mass spectrometers with liquid chromatography interfaces and a MALDI-TOF instrument. Research within the facility ranges from basic physical chemistry and biochemical studies through to proteomics, metabolomics and drug-protein and drug-nucleic acid interactions. Mass spectrometry services are offered to both internal and external customers. For further information contact Dr Colin James
UCL Translational Mass Spectrometry Research Group brings together cutting edge technology with precision and stratified medicine for the benefit of patients. TMSRG specialises in using extreme deep phenotyping (proteomics, metabolomics and lipidomics) to find new drug targets, elucidate disease mechanisms, identify new biomarkers and develop new tests for the NHS and industrial drug trials. If you would like to apply for a grant to use mass spectrometry you must visit the FAQs webpage and contact TMSRG.The Cancer Proteomics Group welcomes collaborative research, offering advice on experimental design and performing sample prep and LC-MS/MS analysis (Orbitrap) using workflows incorporating chemical mass tagging, in vivo labelling (SILAC) and label-free quantification. The group has expertise in the analysis of clinical samples for biomarker discovery and in Machine learning/Artificial Intelligence for data interpretation and modelling using network and longitudinal approaches. For further information contact CPG team.
The PRCF provides infrastructure for protein and PTM identification and quantification and expertise in PTM enrichment strategies, peptide separations and state-of-the-art MS for discovery-driven experiments. The PRCF also develops targeted workflows for quantitative monitoring of pre-selected sets of proteins as well as new sample preparation techniques, MS approaches and software tools to provide optimal analytical solutions. In order to establish a collaboration, you need to submit a project proposal according to facility’s guidelines.
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