Centre for Rheumatology and Connective Tissue Diseases




  1. Nihtyanova SI, Schreiber BE, Ong VH, Rosenberg D, Moinzadeh P, Coghlan JG, WElls AU, Denton CP. Prediction of pulmonary complications and long term survival in systemic sclerosis. Arthritis Rheumatol. 2014 Mar 3. [Epub ahead of print]. APPENDIX. pdf
  2. Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, Bou-Gharios G, Nicholson AG, Denton CP, Grutters JC, Maher TM, Wells AU, Abraham DJ, Renzoni EA. Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease. Respir Res. 2013.
  3. Quillinan NP, McIntosh D, Vernes J, Haq S, Denton CP. Treatment of diffuse systemic sclerosis with hyperimmune caprine serum (AIMSPRO): a phase IIdouble-blind placebo-controlled trial. Ann Rheum Dis. 2013.
  4. Derrett-Smith EC, Dooley A, Gilbane A, Trinder S, Khan K, Baliga R, Holmes A, Hobbs A, Abraham D, Denton CP. Endothelial injury in a TGFβ dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum. 2013.
  5. Maurer B, Distler A, Dees C, Khan K, Denton CP, Abraham D, Gay RE, Michel BA, Gay S, Distler JH, Distler O. Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis. 2013.
  6. Tang X, Peng R, Phillips JE, Deguzman J, Ren Y, Apparsundaram S, Luo Q, Bauer CM, Fuentes ME, DeMartino JA, Tyagi G, Garrido R, Hogaboam CM, Denton CP, Holmes AM, Kitson C, Stevenson CS, Budd DC. Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis. Am J Pathol. 2013 Aug;183(2):470-9.
  7. Poulet B, Westerhof TA, Hamilton RW, Shefelbine SJ, Pitsillides AA.  Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma. Osteoarthritis Cartilage. 2013 May; 21(5): 756-63. doi: 10.1016/j.joca.2013.652. 
  8. Donovan J, Shiwen X, Norman J, Abraham D. Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts. Fibrogenesis Tissue Repair. 2013 May 10;6(1):10. doi: 10.1186/1755-1536-6-10.
  9. Sonnylal S, Xu S, Jones H, Tam A, Sreeram VR, Ponticos M, Norman J, Agrawal P, Abraham D, de Crombrugghe B. Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci. 2013 May 15;126(Pt 10):2164-75.
  10. De Lauretis A, Sestini P, Pantelidis P, Hoyles R, Hansell DM, Goh NS, Zappala CJ, Visca D, Maher TM, Denton CP, Ong VH, Abraham DJ, Kelleher P, Hector L, Wells AU, Renzoni EA. Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis. J Rheumatol. 2013 Apr;40(4):435-46.
  11. Donovan J, Abraham D, Norman J. Platelet-derived growth factor signaling in mesenchymal cells. Front Biosci (Landmark Ed). 2013 Jan 1;18:106-19.
  12. Shi-wen X, Thompson K, Khan K, Liu S, Murphy-Marshman H, Baron M, Denton CP,] Leask A, Abraham DJ. Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. Rheumatology (Oxford). 2012 Dec;51(12):2146-54.
  13. Poulet B, Ulici V, Stone TC, Pead M, Gburcik V, Constantinou E, Palmer DB, Beier F, Timmons JA, Pitsillides AA. Time-series transcriptional profiling yields new perspective on susceptibility to murine osteoarthritis.  Arthritis Rheum. 2012 Oct;64(`0):3256-66. doi: 10.1002/art.34572.
  14. Khan K, Xu S, Nihtyanova S, Derrett-Smith E, Abraham D, Denton CP, Ong VH. Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis. Ann Rheum Dis. 2012 Jul;71(7):1235-42.
  15. Lagares D, Busnadiego O, García-Fernández RA, Kapoor M, Liu S, Carter DE, Abraham D, Shi-Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodríguez-Pascual F. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum. 2012 May;64(5):1653-64.
  16. Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A. Loss of PTEN expression by dermal fibroblasts causes skin fibrosis. J Invest Dermatol. 2011 Oct;131(10):1996-2003.
  17. Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D, Bou-Gharios G. High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Mol Biol Cell. 2011 Jun 1;22(11):1836-44.
  18. Liu S, Shi-wen X, Abraham DJ, Leask A. CCN2 is required for bleomycin-induced nskin fibrosis in mice. Arthritis Rheum. 2011 Jan;63(1):239-46.
  19. Poulet B, Hamilton RW, Shefelbine S, Pitsillides AA. Characterizing a novel and adjustable noninvasive murine joint loading model.  Arthritis Rheum. 2011 Jan;63(1):137-47. doi: 10.1002/art.27765.


  1. Denton CP, Ong VH. Targeted therapies for systemic sclerosis. Nat Rev Rheumatol. 2013 Aug;9(8):451-64.
  2. Gilbane AJ, Denton CP, Holmes AM. Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells. Arthritis Res Ther. 2013 Jun 17;15(3):215.
  3. Donovan J, Abraham D, Norman J. Platelet-derived growth factor signaling in mesenchymal cells. Front Biosci (Landmark Ed). 2013 Jan 1;18:106-19
  4. Moinzadeh P, Denton CP, Abraham D, Ong V, Hunzelmann N, Eckes B, Krieg T. Biomarkers for skin involvement and fibrotic activity in scleroderma. J Eur Acad Dermatol Venereol. 2012 Mar;26(3):267-76.
  5. Tan A, Denton CP, Mikhailidis DP, Seifalian AM. Recent advances in the diagnosis and treatment of interstitial lung disease in systemic sclerosis (scleroderma): a review. Clin Exp Rheumatol. 2011 Mar-Apr;29(2 Suppl 65):S66-74.
  6. Fonseca C, Abraham D, Renzoni EA. Endothelin in pulmonary fibrosis. Am JmRespir Cell Mol Biol. 2011 Jan;44(1):1-10.
  7. Ong VH, Denton CP. Innovative therapies for systemic sclerosis. Curr Opin Rheumatol. 2010 May;22(3):264-72.
  8. Derrett-Smith EC, Denton CP, Sonnylal S. Animal models of scleroderma: lessons mfrom transgenic and knockout mice. Curr Opin Rheumatol. 2009 Nov;21(6):630-5.
  9. Quillinan NP, Denton CP. Disease-modifying treatment in systemic sclerosis: current status. Curr Opin Rheumatol. 2009 Nov;21(6):636-41.

Books and book chapters

We also publish books and book chapters on connective tissue diseases and cardiovascular biology and translational medicine: