Centre for Respiratory Biology


Key Publications

  1. Excess ERK signalling promotes inflammatory signalling in primary airway epithelium expressing Z a1-antitrypsin. E.F.A. van 't Wout, J.A. Dickens, A. van Schadewijk, I. Haq , H-F. Kwok, A. Ordonez, G. Murphy, J. Stolk, D.A. Lomas*, P.S. Hiemstra* and S.J. Marciniak* (*joint senior authors). Hum. Mol. Genet. 2013; in press
  2. Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response inteh dementia FENIB. B.D Roussel, T.M Newton, E. Malzer, N. Simecek, I. Haq, S.E Thomas, M.L Burr, P.J Lehner, D.C. Crowther, S.J Marciniak and D.A Lomas. . Hum. Mol. Genet. 2013; In press.
  3. Endoplasmic reticulum polymers impair luminal protein mobility and sensitise to cellular stress in a1-antitrypsin deficiency. A. Ordonez, E.L. Snapp, L. Tan, E. Miranda, S.J. Marciniak*, D.A. Lomas*. (*joint senior authors). Hepatology 2013; 57:2049-60.
  4. Prevalence and risk factors for liver involvement in individuals with PiZZ-related lung disease. M.F. Dawwas, S.E. Davies, W.J.H. Griffiths, D.A. Lomas and G.J.M. Alexander. Am. J. Resp. Crit. Care Med. 2013; 187: 502-508.
  5. Implications of endoplasmic reticulum dysfunction in neurological disease. B.D. Roussel, A.J. Kruppa, D.C. Crowther, D.A. Lomas, S.J. Marciniak. Lancet Neurology. 2013; 12: 105-118.
  6. Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease. A. Duvoix*, J.A. Dickens*, I. Haq, D. Mannino, B.E. Miller, R. Tal-Singer and D.A. Lomas (joint first* authors). Thorax 2013; 68: 670-676.
  7. Determinants of presence and progression of emphysema in COPD. H.O Coxson, A. Dirksen, L.D. Edwards, J.C. Yates, A. Agusti, P. Bakke, P.M.A. Calverley, B. Celli, C. Crim, D.A. Lomas, W. MacNee, B.E. Miller, S.I. Rennard, E.K. Silverman, R. Tal-Singer, E. Wouters, J. Vestbo for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Lancet Respiratory Medicine. 2013; 1: 129-136.
  8. Sleigh J.N., Buckingham S.D., Esmaeili, B.E., Viswanathan M., Westlund B.M. and Sattelle, D.B. (2011) A novel Caenorhabditis elegans allele smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds. Hum Mol Genet 20, 245-260.
  9. Werren J.H. et al. (2010) Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science 327, 343-348.
  10. Briese, M., Esmaeili, B., Fraboulet, S., Burt, E., Christodoulou, S.C., Towers, P.R., Davies, K.E. and Sattelle, D.B. (2009). Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan.  Hum Mol Genet. 18, 97-104.
  11. Jones A.K., Buckingham S.D., Papadaki M., Yokota M., Sattelle B.M., Matsuda K. and Sattelle D.B. (2009) Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency. J Neuroscience 29, 4287-4292.
  12. Richards, S. et al (2008) The genome of the model beetle and pest Tribolium castaneum (2008) Nature 452, 949- 955.
  13. Weinstock G. et al (2006) Insights into social insects from the genome of the honeybee Apis mellifera Nature 443: 931-949.
  14. Jones, A.K., Buckingham, S.D., and Sattelle, D.B (2005) Chemistry-to-gene screens in Caenorhabditis elegans. Nature Rev. Drug Discov. 4, 321-330.