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Infection, Immunology & Inflammation

The Infection, Immunology and Inflammation (III) Theme is a major grouping of cross-disciplinary expertise that brings together around 250 group leaders and post-doctoral researchers from across UCL.

By working together, UCL III researchers are increasing our understanding of diseases, such as HIV, TB, malaria, asthma, arthritis, and cancer.  This cross-disciplinary culture also provides an excellent training environment for PhD students and post-doctoral scientists.

The UCL III community comes together once a year for the III Symposium, which showcases research activity and stimulates new collaborations.

Below are details and some videos of previous talks at UCL III symposia:

The 2016 UCL Infection, Immunology and Inflammation Symposium was held on Tuesday 8 November at the UCL Institute of Education.

This event, organised by the UCL Personalised Medicine Domain and held in partnership with Queen Mary University of London (QMUL), UCLPartners, and the National Institute for Health Research BRC Infection, Immunity and Inflammation (III) Programme,  brought researchers together from across UCL, QMUL and beyond, enabling cross-disciplinary interaction and encouraging new collaborations.

Eminent speakers from UCL and QMUL presented their ground-breaking work.

The Symposium also featured another popular abstract competition for early career researchers in both the basic and clinical sciences. 

Early career researcher prizes:

  • Presentation winner: Dr Neil McCarthy (Blizard Institute, QMUL), for his presentation on 'Human antigen-presenting yd T-cells promote IL-22 production in naïve and intestinal memory CD4+ T-cells in a TNF-alpha and ICOSL-dependent manner'
  • Poster winner: Lina Petersone (UCL Institute of Immunity and Transplantation) - 'Contribution of IL-21 signalling to the phenotype of CTLA-4 deficient mice'
  • Poster runner-up: Dr Anjum B Khan (UCL Institute of Immunity and Transplantation) - 'Targeting therapeutic T-cells to the bone marrow niche'
  • Poster runner-up: Dr Natalie Suff (UCL Institute of Women's Health) - 'A light-producing mouse model of Infection-related Preterm Birth (PTB)'

This year there was also an additional 3R prize for science or technology development which supports the replacement, reduction and refinement (the 3Rs) of animals in research. The prize was sponsored by the NC3Rs and awarded to Dr Alexander Maini (PhD Student, Centre for Clinical Pharmacology, UCL Division of Medicine) for his poster 'A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation'

Links

2015

On Wednesday 14 October 2015, researchers from across UCL and beyond were brought together for the annual UCL Infection, Immunology and Inflammation (III) Symposium. The event was held in partnership with UCLPartners and around 270 people from UCL and beyond attended. The sessions were also watched online by over 200 people via a live stream. 

The early career researcher (ECR) poster exhibition and presentations proved especially popular, culminating in three awards presented by Professor David Lomas.

Early career researcher prizes:

  • Presentation winner - Stuart Weston (UCL MRC Laboratory for Molecular Cell Biology) for his presentation on 'Interferon Inducible TransMembrane proteins (IFITMs) can restrict alphavirus infection'.
  • Poster winner - Dr Anne Marijn Kramer (UCL Child Health), 'Delineating the impact of scFv affinity on CAR-mediated T cell function'
  • Poster runner up - Marie Pariollaud (University of Manchester Institute of Human Development), 'A novel mechanism links inflammation to the clock through REV-ERBα protein stability'.

Links

2014

The 2014 Symposium was held at the UCL Institute of Child Health on Monday 24 November.

Sessions included:

  • Immunology 
  • Early Career Researcher Presentations
  • Professor Michael Arthur (UCL President and Provost)
  • Professor Sir John Tooke (UCL Vice-Provost (Health) and Head of the UCL School of Life and Medical Sciences and the UCL Medical School
  • Debate: Genome sequencing at birth
  • Infection
  • Inflammation

Early career researcher prizes:

  • Presentation winner: Dr Emma Nicholson (UCL Division of Infection & Immunity)
  • Presentation runner-up: Dr Jimstan Periselneis (UCL Centre for Inflammation & Tissue Repair)
  • Poster winner: Dr David Bending (UCL Institute of Child Health)
  • Poster runner-up: Laura Pallet (UCL Division of Infection & Immunity)

Links

2013

The 2013 Symposium, UCL Infection, Immunology and Inflammation Symposium: Towards Drug Discovery and Stratification, took place on Tuesday 15 October at the UCL Institute of Child Health. 

Sessions included:

  • Infection Genomics: Pathogenesis and Population Spread
  • Poster Presentation Session
  • Cancer Biological Therapy 
  • Inflammation, Tissue Remodelling and Fibrosis

 

Early career researcher prizes:

  • Presentation winner: Dr Sian Henson
  • Presentation runner-up: Dr Sophie Lourenco
  • Poster winner: Dr Boghuma Titanji
  • Poster runner-up: Nisha Kanda, PhD student

Links

2012

The 2012 Symposium was held on 19 October 2012 at the UCL Institute of Child Health.

Sessions included:

  • Infection
  • Simultaneous poster discussion groups: Cancer Immunology, Regulation of Inflammation, Viral Infection
  • Immunology 
  • Inflammation 

Early Career Researcher prizes:

  • Cancer immunology 1st prize: Katharina Bergerhoff
  • Cancer immunology 2nd prize: Judith Siedel
  • Experimental bacteriology 1st prize: Laura Stoffels
  • Regulation of inflammation co-1st prize: Anneleen Bosma
  • Regulation of inflammation co-1st prize: James Heather
  • Regulation of inflammation co-2nd prize: Konstantia-Maria Chavele
  • Regulation of inflammation co-2nd prize: Ashleigh Howes
  • Viral infection 1st prize: Lucy Bell
  • Viral infection 2nd prize: Adam Fletcher

Links

Examples of III Research at UCL

Virology
Professor Greg Towers has shown that blocking HIV infection by 'uncloaking' the virus particles may provide a new way of preventing infection. This work required expertise from several disciplines including virology, immunology and chemistry.

Bacterial infections
Professor Ali Zumla is leading studies to develop new diagnostic tools and treatments for tuberculosis; work that involves biochemistry, cell biology, clinical trials expertise and international collaborations.

Ageing immune system
Professor Arne Akbar has developed new ways to monitor changes in the aging immune system and is interested in how older people respond to infection and inflammation.  This work requires collaboration across the III Theme, with partnerships in clinical and basic biology as well as industry collaborations.

Other areas of focus across the Theme include:

  • Bacterial infections (e.g.TB, Staph aureas), antimicrobial resistance
  • Viruses (e.g. HIV, VZV), anti-viral immunity, and the development of new anti-viral drugs and diagnostics
  • Parasitic diseases (e.g. malaria)
  • Infectious diseases in children
  • Bacterial and viral disease latency (i.e. periods of dormancy) and reactivation
  • Lung infections and lung inflammation
  • Rheumatic and autoimmune diseases such as rheumatoid arthritis and diabetes
  • The effect of ageing on the immune system
  • Cancer immunology and immunotherapy
  • Genetic and computational studies of the immune response (which may help manage disease in the future).

Below is a list of researchers who are currently working in the field at UCL. Click on their names to find their contact details and more information about their work.

Researchers

Below is the link to a list of researchers who are currently working in the field of infection, immunology and inflammation research at UCL. Follow the link to find their contact details and more information about their work.

Infection, Immunology and Inflammation
" "The UCL III community comes together once a year for the III Symposium, which showcases research activity and stimulates new collaborations."