Phenotypes & Association

Psychotic disorders are highly heterogenic in their onset, treatment outcome and symptomatology according to the broad classifications of current diagnostic manuals (DSM-V and ICD10), which complicates the search for underlying causative mechanisms. This project aims to identify measurable biological markers that can be used to understand specific parts of these conditions, and hopefully to untangle the genetic and biological pathways involved in the development of the disorders.

The main phenotypes we work with include:

  • Electroencephalography (EEG): Event-Related Potentials (ERPs), such as the P300 and the Mismatch Negativity, as well as resting state data.
  • Magnetic Resonance Imaging (MRI) including measures of brain volume and cortical thickness
  • Neuropsychological measures of cognition: For example the WEIS intelligence scores, Digit Span & Block Design Testr, and Rey Auditory Verbal Learning Task (RAVLT)