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Psychiatry

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Division of Psychiatry Seminar - Dr Ozioma Okonkwo

21 July 2021, 3:00 pm–4:00 pm

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Title: Worried about Your Risk for Alzheimer’s Disease? There is Something You Can Do about That!

This event is free.

Event Information

Open to

UCL staff | UCL students

Availability

Yes

Cost

Free

Organiser

DoP Seminars

The unprecedented expansion in the elderly segment of the population of high-income nations, coupled with the lack of an effective cure, raises real concerns that Alzheimer’s disease (AD) will become a public health epidemic in the near future. Accordingly, the identification of potential pathways for curbing the progression of the underlying disease process and delaying the onset of symptoms has become a public health imperative. In this lecture, we will present evidence that lifestyle adaptations, specifically physical activity and aerobic fitness, favorably influence AD biomarker profile and cognitive trajectory particularly against the constraints imposed by advancing age and APOE4 genotype, the two best-established risk factors for AD. We will present evidence from both observational and intervention studies, and will mostly focus on midlife which is now known to be a crucial stage for the evolution of AD-related changes.

Dr. Ozioma Okonkwo is an Associate Professor in the Department of Medicine and the Wisconsin Alzheimer’s Disease Research Center at the University of Wisconsin-Madison School of Medicine and Public Health. Dr. Okonkwo's research focuses on clarifying how alterations in the brain and other biomolecules (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in probable Alzheimer’s disease. He is particularly interested in discovering new knowledge concerning the modulation of the link between brain changes and cognitive decline by both modifiable (e.g., cognitively-stimulating activities, physical exercise) and non-modifiable (e.g., genetic vulnerability) factors.