Rotation Project Programme 1 Simon Mead: Targeted genotyping of candidate SNPs identified by exome sequencing as potential risk factors for Creutzfeldt-Jakob diease. Programme 2 Parmjit Jat: Uncoupling infectivity and toxicity in in vitro models of prion-induced toxicity. Programme 3 Tom Cunningham : Transgenic modelling of a novel inherited prion disease associated with PRNP Y163X mutation Programme 4 Peter Klöhn: Identifying the prion interactome in prion-infected cells Programme 5 Wenjuan Zhang: Structural studies on mechanisms of prion-like protein assemblies in neurodegenerative diseases Programme 6 Jonathan Wadsworth: Structural characterisation of mammalian prions Programme 7 Jan Bieschke: Structure and dynamics of prions and their ligand interactions. Graham Jackson: Prion propagation in vitro: elucidating the mechanism of replication Programme 8 John Collinge (Director) : Development of a probe for prion protein ligand binding and propagation. Programme 9 Silvia Purro: Characterisation of Aβ and tau strains