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PRIMENT CTU Collaborations 

Current Collaborations

Trial Name

Title

Research Area

Funding

APPLE-TreeActive Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: Pilot of the intervention and randomised controlled trialDementiaESRC
ANTLERAntidepressants to prevent relapse in depressionPrimary Care/Mental HealthNIHR HTA
Community Navigator TrialRandomised control trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistent depression in secondary mental health servicesMental HealthNIHR HTA
DREAMS STARTA parallel multi-centre randomised controlled trial to determine the clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carersDementiaNIHR
EMBED-CareEmpowering Better End of Life Dementia Care (EMBED-Care) ProgrammeDementiaESRC-NIHR
EPICC-IDClinical and cost effectiveness of a parent mediated intervention to prevent challenging behaviour in preschoolers with moderate to severe learning disability: a randomised controlled trialLearning DisabilitiesNIHR HTA
HipDysEvaluation of aid to diagnosis for congenital dysplasia of the hip in general practice: controlled randomised trialChild HealthNIHR
HomeHealthClinicial and cost-effectiveness of an in-home personalised health promotion intervention enabling independence in older people with mild frailty; a randomised controlled trialCare for Older PeopleNIHR
KIWEA randomised controlled trial of ketogenic diet in treatment of epilepsy in children under the age of two yearsChild HealthNIHR EME
LiGHTHealth-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapyEyesNIHR HTA
LOGICOutcome and predictors of outcome for children and young people referred to UK gender identity developement services: a longitudinal investigation Gender DiversityNIHR
MePFACMethylphenidate vs Placebo for fatigue in advanced cancerPalliative CareNIHR HTA
NIDUS FamilyClinical and cost-effectiveness of a new psychological intervention to support indpendence in Dementia (NIDUS) for family carers and people living with Dementia in their homes: a randomised controlled trialDementiaAlzheimer's Society
NIDUS ProfessionalAssessing the feasibility and acceptability of a home care workers' training and support intervention, from the perspectives of home care workers, clients living with Dementia and family carers: stream three of the NIDUS programmeDementiaAlzheimer's Society
ORBITTherapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents with Tourette Syndrome: an internal pilot study and single-blind randomised controlled trialChild HealthNIHR HTA
PathfinderProblem adaptation therapy for individuals with mild to moderate dementia and depressionDementiaNIHR
PD-CareLive Well with Parkinson's (as part of the the programme personalised care for people with Parkinson's Disease)Parkinson's DiseaseNIHR
Physio4FMDShort duration high intensity physiotherapy for functional motor disorderPhysiotherapyNIHR HTA
PriDemPrimary care led support in Dementia: implementing best practiceDementia Alzheimer's Society
RADARResearch into Antipsychotic Discontinuation And ReductionSevere Mental IllnessNIHR
SIP SMART 2Prehabilitation of swallowing difficulties in people with head and neck cancer: A pilot cluster ranodmised trial and process evaluationCancerNIHR Fellowship
TOPHATTrial of Ondansetron as a Parkinson's HAllucinations TreatmentParkinson's DiseaseParkinson's UK
VIPA randomised controlled trial of the clinical and cost effectiveness of a Victim Improvement Package for the reduction of chronic symptoms of depression or anxiety in older victims of common crime.Mental HealthNIHR PHR

 

Completed Collaborations

Trial Name

Title

Research Area

Funding

Statistical Analysis Plan

Agitation in DementiaThe effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementiaDementiaNIHR HTA 
AMICUSAmisulpiride augmentation in clozapine-unresponsive schizophreniaSevere Mental IllnessNIHR HTA

BID 

(Befriending)

A pilot randomised controlled trial of one-to-one befriending by volunteers, compared to usual care, in reducing symptoms of depression in people with intellectual disabilityMental Health/Learning DisabilitiesNIHR  
BHiRCHReducing rates of avoidable hospital admissions: Optimising an evidence based intervention to improve care for Ambulatory Care Sensitive conditions in nursing homes.Care of Older People NIHR PGfAR
CanACTA feasibility randomised control trial to evaluate the clinical and cost effectiveness of ACT plus treatment as usual (TAU), a Talking Control (TC) plus TAU or TAU alone for the treatment of dysfunction in advanced cancerMental HealthNIHR RfPB
CanTalkThe clinical and cost effectiveness of CBT plus treatment as usual for the treatment of depression in advanced cancer; a randomised controlled trialMental HealthNIHR HTA 
CIRCLERandomised controlled trial of the clinical and cost-effectiveness of a contingency management intervention for reduction of cannabis use and of relapse in early psychosisSevere Mental IllnessNIHR HTA
Contraception ChoicesIncreasing uptake and adherence to long-acting reversible contraceptive methods in young women.Women's HealthNIHR HTA 
The CORE Programme(CRT optimisation and relapse prevention). Optimising team functioning, preventing relapse and enhancing recovery in crisis resolution teamsMental HealthNIHR PGfAR

EBI-LDA feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the communityLearning DisabilitiesNIHR RfPB 
HAUSHome sampling for increasing the uptake of HIV testingInfectionNIHR HTA 
HELPHealthy eating and Lifestyle Programme in adolescent childrenPrimary Care/Child HealthNIHR PGfAR 
HeLP-DDevelopment, evaluation and implementation of a computer-based self-management programme for people with type 2 diabetesE-HealthNIHR PGfAR 
"I can't forget to worry"A pilot randomised controlled trial of CBT for anxiety in people with dementiaDementiaNIHR RfPB
The MARQUE projectManaging agitation and raising quality of life. A project to improve quality of life in people with moderate or severe dementiaDementiaESRC/NIHR

Medication Review ToolDevelopment and preliminary evaluation of a Medication Review Tool for people taking antipsychotic medicationSevere Mental IllnessNIHR RfPB 
MenSSWhat is the clinical and cost effectiveness of condom use training to prevent recurrent sexually transmitted infections?E-Health/

Sexual Health
NIHR HTA 
PANDA RCT & Pilot RCTWhat are the indications for prescribing antidepressants that will lead to a clinical benefit?Mental HealthNIHR PGfAR 
PARTNERThe relative clinical and cost-effectiveness of three contrasting approaches to partner notification for curable sexually transmitted infections: a cluster randomised trial in primary careSexual HealthNIHR HTA 
PBSClinical and cost effectiveness of staff training in positive behaviour support for treating challenging behaviour among people with learning disabilities: a multi-centre cluster randomised trialLearning DisabilitiesNIHR HTA
PiPs2The Prognosis in Palliative care Study IIPalliative CareNIHR HTA
Physio for FMSRandomised feasibility study of a physiotherapy programme for patients with functional motor symptomsMental HealthNIHR Fellowship 
POSITIVEProblem-solving intervention for people who have been recently diagnosed as blind or partially-sightedEyes/Primary CareGuide Dogs for the Blind
PREDICTPREVEvaluating web based information for prevention of depression in general practice: an exploratory randomised controlled trialPrimary Care/Mental HealthEuropean Commission 
PRIDEPromoting Independence in dementiaDementiaESRC/NIHR 
PRIMROSE Programme of the prevention and treatment of cardio-vascular diseases in people with schizophrenia and severe mental illnessesSevere Mental IllnessNIHR PGfAR
PROACT65Multi-centre cluster randomised trial comparing a community group exercise programme with home-based exercise with usual care for people aged 65 and overCare of Older PeopleNIHR 
SCANMOVEDefinition, validation and randomised controlled trial of a new intervention to diagnose motor side-effects of antipsychotics in community mental health servicesSevere Mental Illness  
Shape-Up LDPiloting a weight management programme for overweight and obese persons with mild or moderate learning disabilitiesLearning DisabilitiesNIHR RfPB 
SHEARAlcohol misuse and sexual health: a randomised trial of brief intervention among people attending sexual health clinics

Sexual Health

Alcohol Use

NIHR HTA 
STARTStrategies for relatives study - A pragmatic randomised controlled trial to determine the effectiveness of a manual based coping strategy programme in promoting the mental health of carers of people with Dementia

Mental Health

Dementia

NIHR HTA 
START2QUITA randomised trial to increase the uptake of smoking cessation services using personal targeted risk information and taster sessionsPrimary CareNIHR HTA 
ToSCARandomised controlled trial of the selective serotonin reuptake inhibitor Sertraline versus Congitive Behavioural Therapy for anxiety symptoms in people with Generalised Anxiety Disorder who failed to respond to low intensity psychological interventions as defined by the NICE GAD guidelines

Primary Care

Mental Health

NIHR HTA 
VALIDValuing Active Life in DementiaDementiaNIHR PGfAR
VIDALVitamin D and longevity trial - randomised feasibility studyCancerNIHR HTA 
10 Top TipsRandomised controlled trial of habit-based advice for weight control in general practicePrimary CareMRC NPRI