Translational Myology Laboratory
Translational Myology Laboratory
The Translational Myology Laboratory (PIs Professor Thomas Voit and Dr. Julie Dumonceaux) is focused on the development of innovative treatment approaches for neuromuscular diseases. We use an Adeno-associated-virus (AAV) platform and muscle cell immortalization or iPS techniques to both create disease-relevant cellular and animal models as well as treatment approaches. In these we combine technologies of vector-mediated gene knock-down or gene transfer with other approaches aiming at stabilizing or correcting genetic abnormalities.
Our current work addresses treatment approaches for Facio-scapulo-humeral muscular dystrophy (FSHD), Myotonic Dystrophy, and Duchenne- Becker- and Limb girdle muscular dystrophy. In addition, we investigate general aspects of muscle homeostasis such as myostatin mechanisms and how these can be exploited for ameliorating wasting muscle conditions.
Thomas Voit
Director of NIHR GOSH UCL Biomedical Research Centre
Julie Dumonceaux
Professorial Research Fellow
Virginie Mariot
Senior Research Fellow
Translational Myology Laboratory Lead
Contact
Email: ich.dn.admin@ucl.ac.uk
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH