Previous Data Curators

The WHO Tuberculosis Individual Patient Data (TB-IPD) platform, currently hosted by UCL, builds upon the foundational work initiated by McGill University. The project was led by Professor Dick Menzies and Assistant Professor Jonathon Campbell, together with Tommy Lan, Mayara Bastos, and Andrea Benedetti. This team has been pivotal in managing and analysing TB IPD datasets, particularly in MDR TB from 2010.

Web page: https://www.mcgill.ca/tb/

• Ahuja SD, Ashkin D, Avendano M, Banerjee R, Bauer M, et al; Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB. Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. PLoS Med. 2012;9(8):e1001300. doi: 10.1371/journal.pmed.1001300. Epub 2012 Aug 28. PMID: 22952439; PMCID: PMC3429397.
• Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017; Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, et al; Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. PMID: 30215381; PMCID: PMC6463280.
• Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC,et al; Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis. The Lancet. 2020 Aug 8;396(10248):402-11.   
• Lan Z, Ahmad N, Baghaei P, Barkane L, Benedetti A, et al; Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis. The Lancet Respiratory Medicine. 2020 Apr 1;8(4):383-94.
• Campbell JR, Brode SK, Barry P, Bastos ML, Bonnet M, et al; Association of indicators of extensive disease and rifampin-resistant tuberculosis treatment outcomes: an individual participant data meta-analysis. Thorax. 2024 Feb 1;79(2):169-78.

The 2021 dataset was curated by the University of Sydney under the leadership of Professor Greg Fox and his team: Dr. Tasnim Hasan, Dr. Ellie Medcalf, Dr. Hannah Morgan, and Dr. Timothy Schlub. In addition to serving as data curators, they also contributed patient data to the integrated dataset.

Web page: https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/gregory.fox.html

Tasnim Hasan, Ellie Medcalf, Bern-Thomas Nyang'wa, Erica Egizi, Catherine Berry, Matthew Dodd, et al; The Safety and Tolerability of Linezolid in Novel Short-Course Regimens Containing Bedaquiline, Pretomanid, and Linezolid to Treat Rifampicin-Resistant Tuberculosis: An Individual Patient Data Meta-analysis, Clinical Infectious Diseases, Volume 78, Issue 3, 15 March 2024, Pages 730–741, https://doi.org/10.1093/cid/ciad653

The Desmond Tutu TB Centre (DTTC) is collaborating with the UCL by advising on paediatric and pregnancy data to complete this platform as a valuable source of information. DTTC is an academic research centre located in the Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Cape Town, South Africa. One of its focus’ lies in developing and evaluating child-friendly TB treatment and preventative therapy through clinical trials to allow better access and uptake of TB medicines. The team, led by Professor Anneke Hesseling and Professor Anthony Garcia-Prats, also has extensive experience in conducting large systematic reviews of IPD datasets, which have informed WHO guidelines and policies.

Web page: https://blogs.sun.ac.za/dttc/benefit-kids/

Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, et al; Treatment and outcomes in children with multidrug-resistant tuberculosis: a systematic review and individual patient data meta-analysis. PLoS medicine. 2018 Jul 11;15(7):e1002591.