International comparisons of 'big' health record data: application to cardiovascular diseases
The Problem
Important barriers to the scalable re-use of data for international comparisons. These include (a) historical lack of research into understanding the validity and quality of such data, (b) information governance restrictions on electronic health records (HER) use (c) lack of forum for international collaboration, (d) data coverage and availability may be limited by resources in different countries, (e) lack of metadata format or central repository for describing data elements for different EHR datasets, few available international data standards are to be updated, (f) lack of established methods for the systematic and reproducible definition and sharing of algorithms between researchers.
Our Research
(i) Clinical research exemplars: To address research questions in the prevention and progression of cardiovascular diseases across two or more countries, which can only be tackled using electronic health record data. (ii) Informatics methods: To facilitate the discovery and documentation of contemporary EHR data sources relevant to cardiovascular disease research in countries with diverse healthcare systems by working in close collaboration with experts across the Farr Institute.
Themes
People
Sheng-Chia Chung
Spiros Denaxas
Laura Pasea
Harry Hemingway
Collaborators
Adam Timmis
Mar Pujades Rodriguez
Anoop Dinesh Shah
Tomas Jernberg
Lars Wallentin
Publications
Chung SC, Sundström J, Gale CP, James S, Deanfield J, Wallentin L, Timmis A, Jernberg T, Hemingway H; Comparison of hospital variation in acute myocardial infarction care and outcome between Sweden and United Kingdom: population based cohort study using nationwide clinical registries. BMJ. 2015 Aug 7;351:h3913.
Impact in research
- Blood pressure and incidence of twelve cardiovascular diseases
- Blood tests for the early identification of Alzheimer's Disease
- Breaking records: Using health records to explore antibiotic prescribing practice
- CALIBER cardiovascular disease prevention projects
- Cognitive workload of health technologies
- Heterogeneity of cognitive decline in dementia: taking into account variable time-zero severity
- Infection Response through Virus genomics (ICONIC)
- International comparisons of 'big' health record data: application to cardiovascular diseases
- Investigating adverse effects of psychiatric drugs through data-mining of electronic health records
- KConnect
- Laboratory-confirmed respiratory infections as vascular triggers
- Large scale omics data integration for biomarker discovery, drug repositioning and screening for new therapeutic targets for Alzheimer's disease
- Lipids and cardiovascular diseases in CALIBER
- 'Nothing about us, without us.' Involvement of Experts by Experience in Homeless and Inclusion Health Research
- Prognosis Research Partnership
- Reactivation of varicella zoster virus and vascular outcomes
- Real-time detection of influenza outbreaks in hospitals: demonstrating infection response through virus genomics (ICONIC)
- The prescription-persistence cascade in cardiovascular disease-an opportunity for big data research
- Tuberculosis in migrants
- Video Observed Therapy for TB – The world’s first randomised controlled trial of smartphone enabled “Video Observed Therapy” to support patients to complete tuberculosis treatment