EuroSIDA/MISTRAL

Project summary

Although the microbiome has been the subject of intense research over recent decades, very few publications have addressed its potential role in HIV/AIDS - and most of these have focused on the genital microbiome. Increasing evidence supports a role for the gut microbiome in immune system disorders, chronic inflammation and accelerated ageing, all hallmarks of HIV-1 infection. The EU-funded MISTRAL project is exploring the gut microbiota in relation to HIV-1, seeking microbiome biomarkers to support development of interventions that mitigate infection and enhance response to vaccines and therapies. In addition, the creation of a publicly accessible database will aid inpatient screening and stratification. A cloud-based tool will also facilitate microbiome interpretation for research and clinical purposes.

European Commission: Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Key Project Information

Dates: 2021 - Present

Principal Investigator: Alessandro Cozzi-Lepri (collaborator, not a PI in the grant)

Project Lead: Lars Peters

Partner: CHIP, Copenhagen

Location: Denmark

Funding: Horizon 2020

Contact: a.cozzi-lepri@ucl.ac.uk

Publications

MISTRAL study, Centre of Excellence for Health, Immunity and Infections