Developmental Biology of Birth Defects
The Developmental Biology of Birth Defects Section employs genetic techniques together with cellular, molecular and developmental biology to elucidate mechanisms of morphogenesis and how these are disrupted in human birth defects, including childhood tumours.
Active areas of investigation include spinal cord and brain development, pituitary development, tumour pathogenesis, craniofacial malformation, renal defects and cardiovascular morphogenesis.
Basic research is complemented by clinical translation, for instance through improving diagnosis and treatment of birth defects, the use of micronutrients in prevention of congenital disease, VEGF as a therapy in cystic kidney disease, novel treatments against paediatric brain tumours and efforts towards tissue engineering.
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Section Head
Dr Paula Alexandre
- Telephone (Admin Team): 0207 905 2235
- Send an email to the DBC Admin Team
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Developmental Biology of Birth Defects Section
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH
