Dark Space Project (DSP)

The Dark Space Project is an initiative lead by the IntAct database to capture interaction information that is reported in the literature but is not represented in IMEx databases.

We are contributing to this project by prioritising the curation of a list of human genes known to be related to cardiac risk, and which we extracted from this publication: Global Lipids Genetics Consortium et al., 'Discovery and refinement of loci associated with lipid levels', Nat. Genet., vol. 45, no. 11, pp. 1274-1283, Nov. 2013 (PMID 24097068).

Our priority list contains genes that do not have any interaction data in IMEx databases or in the EBI-GOA-nonIntAct dataset. The latter is curated to the GO (Gene Ontology) standard i.e. not to the deep curation level of IMEx rules.

Here is the list of priority genes:

	HGNC Gene Name	HGNC Gene Symbol
1	ATP-binding cassette sub-family A member 8	ABCA8
2	Cartilage intermediate layer protein 2	CILP2
3	Cytochrome P450 family 26 subfamily A member 1	CYP26A1
4	Cytochrome P450 family 7 subfamily A member 1	CYP7A1
5	Dynein axonemal heavy chain 11	DNAH11
6	Fatty acid desaturase 3	FADS3
7	Krueppel-like factor 14	KLF14
8	Solute carrier family 39 member 8	SLC39A8
9	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	ST3GAL4
10	T-cell immunoglobulin and mucin domain-containing protein 4	TIMD4
11	Aldo-keto reductase family 1 member C4	AKR1C4
12	Angiopoietin like 1	ANGPTL1
13	G protein-coupled receptor 146	GPR146
14	Potassium two pore domain channel subfamily K member 17	KCNK17
15	Olfactory receptor family 4 subfamily C member 46	OR4C46
16	Monoacylglycerol O-acyltransferase 2	MOGAT2
17	Phosphatidylinositol glycan anchor biosynthesis class V	PIGV
18	Hydroxycarboxylic acid receptor 2	HCAR2
19	Ribosomal RNA adenine dimethylase domain containing 1	RRNAD1
20	Zinc finger DHHC-type containing 18	ZDHHC18

The Functional Gene Annotation team is supported by Alzheimer's Research UK (grants ARUK-NAS2017A-1 and ARUK-NSG2018-003) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.