Current PhD studentships

A funded 3-year PhD at UCL Great Ormond Street Institute of Child Health, in collaboration with Great Ormond Street Hospital, developing innovative technologies to improve care for children.

This PhD project investigates lentiviral gene therapy to correct immune dysfunction in children with mevalonate kinase deficiency by restoring MVK activity in stem cells and macrophages.

This PhD develops a tissue-engineered oesophagus for children born without a stomach connection, focusing on safe graft production, oxygen control, and tracking transplanted cells in the body.

This PhD project develops gene therapies for neurodevelopmental disorders by using genome editing to restore expression of haploinsufficient genes in patient-derived cell models.

This PhD explores how epigenetic mechanisms like DNA methylation and histone modification influence disease variability and may uncover modifiers of monogenic disorders.

This PhD investigates how loss of primary cilia and BBSome function triggers fibrosis, aiming to uncover signalling pathways that drive scar formation across organs and identify therapeutic targets.

This PhD investigates how defective motile cilia cause mucus buildup and lung damage in PCD, aiming to uncover disease mechanisms and develop new therapies for this rare respiratory disorder.

This PhD investigates how novel ciliary genes regulate hypothalamic development and neuroendocrine function, aiming to uncover links to metabolic, behavioural, and neurodevelopmental disorders.

This PhD uses advanced diffusion MRI to map brain microstructure in children with epilepsy, aiming to predict cognitive and seizure outcomes and support personalised surgical decision-making.

This PhD investigates how human germ cells transition to pluripotency, aiming to uncover signalling pathways and develop new stem cell models to advance reproductive and developmental biology.

This PhD explores how whole genome sequencing can enable lifelong pharmacogenomic profiling in children, improving medication safety and reducing adverse drug reactions in NHS care.

This PhD explores gene therapy for severe alpha thalassemia, aiming to overcome challenges in targeting and correcting stem cells to enable curative treatment before birth.

This PhD explores rare paediatric gastric diseases using advanced multi-regional assembloids to model region-specific pathology and epithelial–mesenchymal interactions in vitro.

This PhD investigates how genetic and nutritional disruption of folate metabolism contributes to birth defects like cleft palate, heart anomalies, and neural tube defects.

This PhD investigates how Trisomy 21 affects brain development and tumour risk, exploring changes in progenitor zones and anti-tumour microenvironments in Down Syndrome.