Neurodegenerative Diseases
My research revolves around leveraging human induced pluripotent stem cells (iPSCs) as a pre-clinical model to investigate the crucial role of endolysosomal dysfunction in neurodegenerative diseases.
Biography
Christy Hung is a Race Against Dementia Fellow and Alzheimer's Research UK Senior Fellow at UCL and the Francis Crick Institute.
Research
My research interests and expertise revolve around leveraging human induced pluripotent stem cells (iPSCs) as a pre-clinical model to investigate the crucial role of endolysosomal dysfunction in neurodegenerative diseases.
UCL Appointments
- Research Fellow
University College London, Developmental Biology & Cancer Dept
Academic Positions
- Race Against Dementia Fellow
University of London, London, 2019 - present - Alzheimer's Research UK Senior Fellow
University College London, London, 2023 - present
Fields of Research
- Neurosciences
- Neurology and neuromuscular diseases
- Protein trafficking
- Biochemistry and cell biology
Hung C, Patani R, 4R tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia, Autophagy, doi: 10.1080/15548627.2023.2300917
2023Hung C, Patani R, Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia, Brain, doi: 10.1093/BRAIN/AWAD370
2021Hung C, Tuck E, Stubbs V, Van der Lee SJ, Aalfs C, Van Spaendonk R, Scheltens P, Hardy J, Holstege H, Livesey FJ, SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network, Cell Reports, doi: 10.1016/J.CELREP.2021.109259
Hung C, Livesey FJ, Endolysosome and autophagy dysfunction in Alzheimer disease, Autophagy, doi: 10.1080/15548627.2021.1963630
Hung C, Importance of retrograde axonal transport in mitochondrial health and distribution, Cell Death Discovery, doi: 10.1038/S41420-021-00502-3
2018Hung C, Livesey FJ, Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease, Cell Reports, doi: 10.1016/J.CELREP.2018.11.095
2017Hung C, Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human Neurons, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.3688-16.2017
2016Hung C, Coleman MP, KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons, Traffic, doi: 10.1111/TRA.12428
Dr Christy Hung
Research Fellow
Developmental Biology & Cancer Dept
UCL GOS Institute of Child Health
Email: christy.hung@ucl.ac.uk