Paediatric Neuropathology Group
Our aim is to understand the cellular mechanisms that underlie childhood brain diseases and improve diagnosis for children. We focus on brain tumours and epilepsy.
Biography
I am the Professor of Paediatric Neuropathology at the UCL Great Ormond Street Institute of Child Health and Clinical Lead/Laboratory Director for the department of histopathology at Great Ormond Street Hospital for Children. I run a research programme focussed on paediatric brain tumours and epilepsy. I provide a diagnostic service in paediatric neuropathology. I am Editor in Chief of Neuropathology and Applied Neurobiology and the national lead for the Childhood Solid Tumour domain of the Genomics England Clinical Interpretation Partnership. I was an editor of the WHO classification of childhood tumours (5th edition), and I am a member of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW).
Research
The aim of our group is to understand the development of paediatric brain diseases and in particular to improve diagnosis. We focus on brain tumours and epilepsy.
Conditions: Astrocytoma, Brain tumours in children, Focal Cortical Dysplasia, Epilepsy
Neurogenesis ,Neuropathology, Progenitors, Stem cells, Temporal lobes
Methods: Cell culture, Confocal microscopy, Gene expression profiling - tissue level, Histology, Immunohistochemistry, light microscopic techniques, Time-lapse imaging, Stereological analysis
UCL Appointments
- Professor of Paediatric Neuropathology
University College London, Developmental Biology & Cancer Dept
Degrees
- Fellow of the Royal College of Pathologists
Royal College of Pathologists, UK, 2008 - Member of the Royal College of Pathologists
Royal College of Pathologists, UK, 2007 - Member of the Royal College of Physicians
Royal College of Physicians, 2000 - Doctor of Philosophy
University of Cambridge, 1998 - Bachelor of Medicine, Bachelor of Surgery
University of Cambridge, 1997 - Master of Arts
University of Cambridge, 1996 - Bachelor of Arts
University of Cambridge, 1992
Fields of Research
- Brain
- Brain Tumour
- Cancer
- Epilepsy
- Focal Cortical Dysplasia
- Morphology
- Neural stem cells
- Neuroanatomy
Active publication list available on Professor Thomas Jacques's UCL Profiles Page
Professor of Paediatric Neuropathology
Developmental Biology and Cancer Research & Teaching Department
UCL Great Ormond Street Institute of Child Health
Contact Details:
Developmental Biology and Cancer Research and Teaching Department
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH
