Childhood Leukaemia

The research in this group is focused on understanding mechanisms involved in the development, maintenance and drug resistance of paediatric acute leukaemia.

Research

Chromosomal translocations are frequent in infant and childhood leukaemia. These translocations often result in the generation of unique fusion genes. We investigate the function of fusion genes and downstream mediators that are commonly associated with infant and childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), using molecular and cellular modelling approaches. The goal of this research is to develop novel therapeutic approaches for leukaemia that are difficult to treat with conventional chemotherapy.

UCL Appointments
  • Professor of Cancer Biology
Degrees
  • Doctor of Philosophy
    University College London, 1991
  • Bachelor of Science (Honours)
    University College London, 1987
Fields of Research
  • Cardiovascular medicine and haematology
  • Immunology
  • Cardiovascular medicine and haematology
  • Paediatrics

Clemence Virely
Post Doctoral Fellow
c.virely@ucl.ac.uk

Noelia Che
Post Doctoral Fellow
n.che@ucl.ac.uk

Danesh Sundar
PhD student
danesh.sundar.17@ucl.ac.uk

Olivia Ciampa
Post Doctoral Fellow
o.ciampa@ucl.ac.uk

Harsh Bumia
PhD student
harsh.bumia.21@ucl.ac.uk

 

Owen Williams
Professor Owen Williams

Professor of Cancer Biology

Developmental Biology & Cancer Dept
UCL GOS Institute of Child Health

Contact Details:

owen.williams@ucl.ac.uk

Developmental Biology and Cancer Research and Teaching Department
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH