MMTRC Publications

PUBLICATIONS ACKNOWLEDGING SUPPORT FROM THE STRATEGIC PRIORITY FUND ‘TACKLING MULTIMORBIDITY AT SCALE’ PROGRAMME MR/V033867/1 FOR MMTRC.

Alasdair N Warwick, Aroon D Hingorani, Anthony P Khawaja, María Gordillo-Marañón, Abraham Olvera-Barrios, Kelsey V Stuart, Catherine Egan, Adnan Tufail, Reecha Sofat, Valerie Kuan Po Ai, Chris Finan, Amand F Schmidt. Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation – ‘MR Fish’. medRxiv 2024.07.11.24310200; doi: https://doi.org/10.1101/2024.07.11.24310200

Gordillo-Marañón, M., Schmidt, A.F., Warwick, A. et al. Disease coverage of human genome-wide association studies and pharmaceutical research and development. Commun Med 4, 195 (2024). https://doi.org/10.1038/s43856-024-00625-5

Langenberg, C., Hingorani, A.D. & Whitty, C.J.M. Biological and functional multimorbidity—from mechanisms to management. Nat Med 29, 1649–1657 (2023). https://doi.org/10.1038/s41591-023-02420-6

Kuan V, Denaxas S, Hingorani AD et al on behalf of on behalf of the Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study.  The Lancet Digital Health. 2022 Nov.  Available online. DOI: https://doi.org/10.1016/S2589-7500(22)00187-X Plain English summary by PPI group here

Schmidt AF, Hunt NB, Gordillo-Marañón M, et al. Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Nature Communications. 2021 Sep;12(1):5640. DOI: 10.1038/s41467-021-25703-3. PMID: 34561430; PMCID: PMC8463530.

Pietzner M, Wheeler E, Carrasco-Zanini J, et al. Mapping the proteo-genomic convergence of human diseases. Science (New York, N.Y.). 2021 Nov;374(6569):eabj1541. DOI: 10.1126/science.abj1541. PMID: 34648354.

Gordillo-Marañón M, Zwierzyna M, Charoen P, et al. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nature Communications. 2021 Oct;12(1):6120. DOI: 10.1038/s41467-021-25731-z. PMID: 34675202; PMCID: PMC8531035.

Schmidt AF, Hingorani AD, Finan C. Human Genomics and Drug Development. Cold Spring Harbor Perspectives in Medicine. 2022 Feb;12(2):a039230. DOI: 10.1101/cshperspect.a039230. PMID: 34649961.

Henry A, Gordillo-Marañón M, Finan C, et al. Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. Circulation. 2022 Apr;145(16):1205-1217. DOI: 10.1161/circulationaha.121.056663. PMID: 35300523; PMCID: PMC9010023.

Schmidt A, Bourfiss M, Alasiri A, Chopade S, Puyol-Anton E, Vugt M, Laan S... Finan C. (2022). Druggable proteins influencing cardiac structure and function: implications for heart failure therapies and cancer related cardiotoxicity. Researchgate. (Preprint)

Polygenic scores in disease prediction: evaluation using the relevant performance metrics. AD. Hingorani, J. Gratton, C. Finan, AF. Schmidt, R. Patel, R. Sofat, V. Kuan, C. Langenberg, H. Hemingway, JK. Morris, NJ. Wald MedRxiv  doi: https://doi.org/10.1101/2022.02.18.22271049 (Preprint)

Related or supporting work from MMTRC investigators

Lai AG, Chang WH, Parisinos CA, et al. An informatics consult approach for generating clinical evidence for treatment decisions. BMC Medical Informatics and Decision Making. 2021 Oct;21(1):281. DOI: 10.1186/s12911-021-01638-z. PMID: 34641870; PMCID: PMC8506488.

Denaxas S, Liu G, Feng Q, et al. Mapping the Read2/CTV3 controlled clinical terminologies to Phecodes in UK Biobank primary care electronic health records: implementation and evaluation. AMIA ... Annual Symposium proceedings. AMIA Symposium. 2021;2021:362-371. PMID: 35308936; PMCID: PMC8861677.

Fraser HC, Kuan V, Johnen R, et al. Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging Cell. 2022 Apr;21(4):e13524. DOI: 10.1111/acel.13524. PMID: 35259281; PMCID: PMC9009120.