CAESAR: Children's Advanced Epilepsy Surgery and Research

• Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET) Project

The CADET Project is a series of consecutive clinical device trials that aim to investigate the safety, feasibility and effectiveness of thalamic DBS to treat children with Lennox-Gastaut syndrome.  

• Thalamic Recordings in Children Undergoing SEEG (TRICS)

We are systematically recording from 3 different areas of the thalamus in children undergoing stereoelectroencephalography (SEEG) as part of their work-up for epilepsy surgery at GOSH. This will enable us to identify variability in involvement of these regions in epilepsy and identify potential targets for Deep Brain Stimulation (DBS).

• Structural Brain Network Alterations in Focal Epilepsy

We have conducted research to show that the brains of children with epilepsy are wired differently to those without using diffusion MRI scans. We are looking to improve the management of children by using this information to help plan further management.

• Children’s Adaptive DBS for Focal Epilepsy (CADET-F)

A project currently in set-up. For children who have taken part in TRICS and who continue to have seizures, we will run a clinical trial of personalised DBS with the aim of improving seizures. 

• Advanced 7T MRI for presurgical evaluation in epilepsy surgery

In collaboration with partners across London, we are conducting a study to see whether a more powerful MRI scanner can help better identify lesions causing epilepsy, which can be difficult to spot using current technology. 

Below, you will find a list of scientific publications involving members of our team. Many of them are truly collaborative projects, involving clinicians and researches from all around the world in addition to member of our team. The most recent publications are listed first.

Cohen NT, Li X, Berl MM, Oluigbo CO, Shirozu H, Berkovic SF, Zacharin M, Maixner W, Schulze-Bonhage A, Klotz K, Specchio N, Ferrand-Sorbets S, Bulteau C, Arzimanoglou AA, Regis J, Cross JH, Tisdall MM, Richardson H, Cukiert A, Cukiert C, Jacobs J, Donner EJ, Pearl PL, Kerrigan JF, Wilfong AA, Yuen KCJ, Dlugos DJ, Curry D, Ali I, Ragheb J, Soeby L, Webster E, Gaillard WD (2026) 'International Consensus on the Evaluation and Management of Hypothalamic Hamartomas: Results From a Modified Delphi Survey.' Neurology, 106 (7): e214760. PMID: 41818657

Okoroafor F, Qiang Z, Rosenke S, Chari A, Moeller F, Piper RJ, Baldeweg T, Denison T, Tisdall M () 'Neurophysiologic Biomarkers of Invasive Neuromodulation Therapy for Epilepsy.' Neuromodulation, In Press .PMID: 41805278

Gogou M, Barnes N, Carter S, Elliott C, D'Arco F, Gan HW, Rosenke S, Tisdall MM, Varadkar S (2026) 'Appetite and body weight changes after MR-guided laser interstitial thermal therapy of hypothalamic hamartomas in children with drug-resistant epilepsy.' Seizure, 137 (): 7-16. PMID: 41747505

Feng X, Chari A, Eriksson MH, Prentice F, He X, Xie H, Sepeta L, Tahir MZ, Clayden JD, Tisdall MM, Baldeweg T, Piper RJ () 'Distinct thalamic functional connectivity and volume patterns across focal epilepsies in children: A multimodal neuroimaging study.' Epilepsia, In Press .PMID: 41603169

Piper RJ, Feng X, Chari A, Eriksson MH, Wagstyl K, Seunarine K, Hall G, Taylor PN, Wang Y, Clayden JD, Clark CA, Tahir MZ, Carmichael DW, Baldeweg T, Tisdall MM () 'Thalamocortical structural connectivity in children with focal epilepsy: A diffusion MRI, case-control study.' Epilepsia, In Press .PMID: 41553602

Benjaber M, Zamora M, Toth R, Fleming JE, Landin K, Marks VS, Crockett RA, Ryou JW, Deli A, Green AL, Piper RJ, Tisdall MM, Dijk DJ, Schiff ND, Sharott A, Purpura KP, Baker JL, van Rheede JJ, Denison TJ () 'A clinical grade neurostimulation implant for hierarchical control of physiological activity.' bioRxiv, In Press .PMID: 41279757

Sanders MWCB, Ebel M, Chari A, Fleumer M, Vasilica AM, Eriksson MH, Tisdall M, Splitkova B, Belohlavkova A, Otte WM, Jansen FE, Cross JH, Braun KPJ, Krsek P (2025) 'What determines the timing of epilepsy surgery in children with cortical malformations and low-grade epilepsy-associated tumors?' Epilepsia Open, 10 (5): 1345-1352. PMID: 40767023

Dhaliwal JK, Ruiz-Perez M, Chari A, Piper RJ, Tisdall MM, Hart M (2025) 'Deep brain stimulation for epilepsy: A systematic review and meta-analysis of randomized and non-randomized studies of thalamic targeting.' Epilepsy Res, 216 (): 107607. PMID: 40516441

Qiang Z, Norris J, Cooray G, Rosch R, Miller K, Hermes D, Chari A, Tisdall M (2025) 'Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.' Epilepsia, 66 (9): 3087-3104. PMID: 40407405

Rados M, Beerepoot S, Tisdall MM, Pressler RM, Cross JH, Thornton RC, Diehl B, McEvoy AW, Miserocchi A, Sander JW, Duncan JS, de Tisi J, Cardinale F, Tassi L, Russo GL, Francione S, Lamberink HJ, Leijten FSS, Otte WM, van der Salm SMA, Braun KPJ, van Eijsden P (2025) 'Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers.' Epilepsia, 66 (8): 2715-2727. PMID: 40392123

Ramantani G, Cserpan D, Tisdall M, Otte WM, Dorfmüller G, Jambaqué I, Cross JH, van Schooneveld M, van Eijsden P, Reuner G, Krayenbühl N, Ferrand-Sorbets S, Zentner J, Braun KPJ, Bulteau C (2025) 'Determinants of intellectual and developmental outcomes in a multicenter pediatric hemispherotomy cohort.' Epilepsia, 66 (7): 2213-2224. PMID: 40152452

Tumpa S, Thornton R, Tisdall MM, Baldeweg T, Friston KJ, Rosch RE (2025) 'Interictal discharges spread along local recurrent networks between tubers and surrounding cortex.' J Physiol, 603 (8): 2425-2441. PMID: 40096620

Dasgupta D, Elliott CA, O'Keeffe AG, Rodionov R, Li K, Vakharia VN, Mirza FA, Tahir MZ, Tisdall MM, Miserocchi A, McEvoy AW, Ourselin S, Sparks RE, Duncan JS (2025) 'Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning.' Front Neurol, 16 (): 1514442. PMID: 40083454

Chari A, Piper RJ, Wilson-Jeffers R, Ruiz-Perez M, Seunarine K, Tahir MZ, Clark CA, Rosch R, Scott RC, Baldeweg T, Tisdall MM (2025) 'Longitudinal alterations in brain networks and thalamocortical connectivity in paediatric focal epilepsy: a structural connectomics pilot study.' Brain Commun, 7 (1): fcaf081. PMID: 40040839

Ripart M, Spitzer H, Williams LZJ, Walger L, Chen A, Napolitano A, Rossi-Espagnet C, Foldes ST, Hu W, Mo J, Likeman M, Rüber T, Caligiuri ME, Gambardella A, Guttler C, Tietze A, Lenge M, Guerrini R, Cohen NT, Wang I, Kloster A, Pinborg LH, Hamandi K, Jackson G, Tortora D, Tisdall M, Conde-Blanco E, Pariente JC, Perez-Enriquez C, Gonzalez-Ortiz S, Mullatti N, Vecchiato K, Liu Y, Kalviainen R, Sokol D, Shetty J, Sinclair B, Vivash L, Willard A, Winston GP, Yasuda C, Cendes F, Shinohara RT, Duncan JS, Cross JH, Baldeweg T, Robinson EC, Iglesias JE, Adler S, Wagstyl K, Wagstyl K (2025) 'Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study.' JAMA Neurol, 82 (4): 397-406. PMID: 39992650

Dasgupta D, Chari A, Khan M, Moeller F, Tahir Z, McEvoy AW, Miserocchi A, Duncan JS, Sparks RE, Tisdall M (2025) 'Refining computer-assisted SEEG planning with spatial priors - A novel comparison of implantation strategies across adult and paediatric centres.' Neurophysiol Clin, 55 (1): 103038. PMID: 39808968

Pastore LV, Sudhakar SV, Mankad K, De Vita E, Biswas A, Tisdall MM, Chari A, Figini M, Tahir MZ, Adler S, Moeller F, Cross JH, Pujar S, Wagstyl K, Ripart M, Löbel U, Cirillo L, D'Arco F (2025) 'Integrating standard epilepsy protocol, ASL-perfusion, MP2RAGE/EDGE and the MELD-FCD classifier in the detection of subtle epileptogenic lesions: a 3 Tesla MRI pilot study.' Neuroradiology, 67 (3): 665-675. PMID: 39441414

Adegboyega G, Momin S, Gillespie CS, Jeelani NUO, Sudhakar S, Mankad K, Tisdall MM, Aquilina K, Toescu SM (2024) 'Intraoperative MRI in pediatric epilepsy and neuro-oncology: a systematic review and meta-analysis.' J Neurosurg Pediatr, 34 (6): 628-641. PMID: 39303299

Ramantani G, Cserpan D, Zentner J, Tisdall MM, Braun KP (2024) 'Reader Response: Comparison of Hemispheric Surgery Techniques for Pediatric Drug-Resistant Epilepsy: An Individual Patient Data Meta-Analysis.' Neurology, 103 (2): e209329. PMID: 38896822

Eriksson MH, Prentice F, Piper RJ, Wagstyl K, Adler S, Chari A, Booth J, Moeller F, Das K, Eltze C, Cooray G, Perez Caballero A, Menzies L, McTague A, Shavel-Jessop S, Tisdall MM, Cross JH, Martin Sanfilippo P, Baldeweg T (2024) 'Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?' Brain, 147 (8): 2791-2802. PMID: 38643018

van Dalen T, Kirkham JF, Chari A, D'Arco F, Moeller F, Eltze C, Cross JH, Tisdall MM, Thornton RC (2024) 'Characterizing Frontal Lobe Seizure Semiology in Children.' Ann Neurol, 95 (6): 1138-1148. PMID: 38624073

Salim O, Chari A, Ben Zvi I, Batchelor R, Jones M, Baldeweg T, Cross JH, Tisdall M (2024) 'Patient, parent and carer perspectives surrounding expedited paediatric epilepsy surgery.' Epilepsy Res, 200 (): 107309. PMID: 38286106

Fleming JE, Benjaber M, Toth R, Zamora M, Landin K, Kavoosi A, Ottoway J, Gillbe T, Piper RJ, Noone T, Campbell H, Gillbe I, Kaliakatsos M, Tisdall M, Valentin A, Denison T (2023) 'An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification.' Annu Int Conf IEEE Eng Med Biol Soc, 2023 (): 1-6. PMID: 38083730

Piper RJ, Ibrahim GM, Tisdall MM (2024) 'Deep Brain Stimulation for Children with Generalized Epilepsy.' Neurosurg Clin N Am, 35 (1): 17-25. PMID: 38000839

Salim O, Chari A, Zvi IB, Batchelor R, Baldeweg T, Helen Cross J, Tisdall M (2023) 'Clinician views regarding early surgery for paediatric epilepsy.' Seizure, 113 (): 80-85. PMID: 38000223

Ramantani G, Cserpan D, Tisdall M, Otte WM, Dorfmüller G, Cross JH, van Schooneveld M, van Eijsden P, Nees F, Reuner G, Krayenbühl N, Zentner J, Bulteau C, Braun KPJ (2024) 'Determinants of Functional Outcome after Pediatric Hemispherotomy.' Ann Neurol, 95 (2): 377-387. PMID: 37962290

Roth J, Bergman L, Weil AG, Brunette-Clement T, Weiner HL, Treiber JM, Shofty B, Cukiert A, Cukiert CM, Tripathi M, Sarat Chandra P, Bollo RJ, Machado HR, Santos MV, Gaillard WD, Oluigbo CO, Ibrahim GM, Jallo GI, Shimony N, O'Neill BR, Budke M, Pérez-Jiménez MÁ, Mangano FT, Iwasaki M, Iijima K, Gonzalez-Martinez J, Kawai K, Ishishita Y, Elbabaa SK, Bello-Espinosa L, Fallah A, Maniquis CAB, Ben-Zvi I, Tisdall M, Panigrahi M, Jayalakshmi S, Blount JP, Dorfmüller G, Bulteau C, Stone SS, Bolton J, Singhal A, Connolly M, Alsowat D, Alotaibi F, Ragheb J, Uliel-Sibony S (2023) 'Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: A multicenter, multinational study.' Epilepsia, 64 (12): 3205-3212. PMID: 37823366

Knöpfel N, Zecchin D, Richardson H, Polubothu S, Barberan-Martin S, Cullup T, Gholam K, Heales S, Krywawych S, López-Balboa P, Muwanga-Nanyonjo N, Ogunbiyi O, Puvirajasinghe C, Solman L, Swarbrick K, Syed SB, Tahir Z, Tisdall MM, Allgrove J, Chesover AD, Aylett SE, Jacques TS, Hannan FM, Löbel U, Semple RK, Thakker RV, Kinsler VA (2024) 'GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.' J Invest Dermatol, 144 (4): 820-832.e9. PMID: 37802294

Chari A, Adler S, Wagstyl K, Seunarine K, Tahir MZ, Moeller F, Thornton R, Boyd S, Das K, Cooray G, Smith S, D'Arco F, Baldeweg T, Eltze C, Cross JH, Tisdall MM (2024) 'Lesion detection in epilepsy surgery: Lessons from a prospective evaluation of a machine learning algorithm.' Dev Med Child Neurol, 66 (2): 216-225. PMID: 37559345

Lombardi S, Tortora D, Picariello S, Sudhakar S, De Vita E, Mankad K, Varadkar S, Consales A, Nobili L, Cooper J, Tisdall MM, D'Arco F (2023) 'Intraoperative MRI Assessment of the Tissue Damage during Laser Ablation of Hypothalamic Hamartoma.' Diagnostics (Basel), 13 (14): . PMID: 37510075

Piper RJ, Dasgupta D, Eriksson MH, Ripart M, Moosa A, Chari A, Seunarine KK, Clark CA, Duncan JS, Carmichael DW, Tisdall MM, Baldeweg T (2023) 'Extent of piriform cortex resection in children with temporal lobe epilepsy.' Ann Clin Transl Neurol, 10 (9): 1613-1622. PMID: 37475156

Eriksson MH, Whitaker KJ, Booth J, Piper RJ, Chari A, Martin Sanfilippo P, Caballero AP, Menzies L, McTague A, Adler S, Wagstyl K, Tisdall MM, Cross JH, Baldeweg T (2023) 'Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes.' Epilepsia, 64 (9): 2260-2273. PMID: 37264783

Lee KS, Seunarine KK, Barnes N, Tahir MZ, Varadkar SM, Tisdall MM (2023) 'Accuracy of robot-assisted stereotactic MRI-guided laser ablation in children with epilepsy.' J Neurosurg Pediatr, 32 (2): 214-222. PMID: 37209074

Eriksson MH, Ripart M, Piper RJ, Moeller F, Das KB, Eltze C, Cooray G, Booth J, Whitaker KJ, Chari A, Martin Sanfilippo P, Perez Caballero A, Menzies L, McTague A, Tisdall MM, Cross JH, Baldeweg T, Adler S, Wagstyl K (2023) 'Predicting seizure outcome after epilepsy surgery: Do we need more complex models, larger samples, or better data?' Epilepsia, 64 (8): 2014-2026. PMID: 37129087

Vasilica AM, Winsor A, Chari A, Scott R, Baldeweg T, Tisdall M (2023) 'The influence of disease course and surgery on quality of life in children with focal cortical dysplasia and long-term epilepsy-associated tumours: A systematic review and meta-analysis.' Epilepsy Res, 192 (): 107132. PMID: 37023554

Ramantani G, Bulteau C, Cserpan D, Otte WM, Dorfmüller G, Cross JH, Zentner J, Tisdall M, Braun KPJ (2023) 'Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy.' Epilepsia, 64 (5): 1214-1224. PMID: 36869851

Castro-Villablanca F, Moeller F, Pujar S, D'Arco F, Scott RC, Tahir MZ, Tisdall M, Cross JH, Eltze C (2022) 'Seizure outcome determinants in children after surgery for single unilateral lesions on magnetic resonance imaging: Role of preoperative ictal and interictal electroencephalography.' Epilepsia, 63 (12): 3168-3179. PMID: 36177545

Spitzer H, Ripart M, Whitaker K, D'Arco F, Mankad K, Chen AA, Napolitano A, De Palma L, De Benedictis A, Foldes S, Humphreys Z, Zhang K, Hu W, Mo J, Likeman M, Davies S, Güttler C, Lenge M, Cohen NT, Tang Y, Wang S, Chari A, Tisdall M, Bargallo N, Conde-Blanco E, Pariente JC, Pascual-Diaz S, Delgado-Martínez I, Pérez-Enríquez C, Lagorio I, Abela E, Mullatti N, O'Muircheartaigh J, Vecchiato K, Liu Y, Caligiuri ME, Sinclair B, Vivash L, Willard A, Kandasamy J, McLellan A, Sokol D, Semmelroch M, Kloster AG, Opheim G, Ribeiro L, Yasuda C, Rossi-Espagnet C, Hamandi K, Tietze A, Barba C, Guerrini R, Gaillard WD, You X, Wang I, González-Ortiz S, Severino M, Striano P, Tortora D, Kälviäinen R, Gambardella A, Labate A, Desmond P, Lui E, O'Brien T, Shetty J, Jackson G, Duncan JS, Winston GP, Pinborg LH, Cendes F, Theis FJ, Shinohara RT, Cross JH, Baldeweg T, Adler S, Wagstyl K (2022) 'Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study.' Brain, 145 (11): 3859-3871. PMID: 35953082

Saenz A, Singh J, Gan HW, Varadkar SM, Tisdall MM (2023) 'A novel technique for frame-based MR-guided laser ablation in an infant.' Childs Nerv Syst, 39 (2): 497-503. PMID: 35925382

Hale AT, Chari A, Scott RC, Helen Cross J, Rozzelle CJ, Blount JP, Tisdall MM (2022) 'Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?' Brain, 145 (11): 3755-3762. PMID: 35883201

Piper RJ, Richardson RM, Worrell G, Carmichael DW, Baldeweg T, Litt B, Denison T, Tisdall MM (2022) 'Towards network-guided neuromodulation for epilepsy.' Brain, 145 (10): 3347-3362. PMID: 35771657

Chari A, Seunarine KK, He X, Tisdall MM, Clark CA, Bassett DS, Scott RC, Rosch RE (2022) 'Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.' Commun Biol, 5 (1): 394. PMID: 35484213

Khan M, Chari A, Seunarine K, Eltze C, Moeller F, D'Arco F, Thornton R, Das K, Boyd S, Helen Cross J, Zubair Tahir M, Tisdall MM (2022) 'Proportion of resected seizure onset zone contacts in pediatric stereo-EEG-guided resective surgery does not correlate with outcome.' Clin Neurophysiol, 138 (): 18-24. PMID: 35364463

Chari A, Adler S, Wagstyl K, Seunarine K, Marcus H, Baldeweg T, Tisdall M (2022) 'IDEAL approach to the evaluation of machine learning technology in epilepsy surgery: protocol for the MAST trial.' BMJ Surg Interv Health Technol, 4 (1): e000109. PMID: 35136859

Rados M, Mouthaan B, Barsi P, Carmichael D, Heckemann RA, Kelemen A, Kobulashvili T, Kuchukhidze G, Marusic P, Minkin K, Tisdall M, Trinka E, Veersema T, Vos SB, Wagner J, Braun K, van Eijsden P (2022) 'Diagnostic value of MRI in the presurgical evaluation of patients with epilepsy: influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium.' Epileptic Disord, 24 (2): 323-342. PMID: 34961746

Wagstyl K, Whitaker K, Raznahan A, Seidlitz J, Vértes PE, Foldes S, Humphreys Z, Hu W, Mo J, Likeman M, Davies S, Lenge M, Cohen NT, Tang Y, Wang S, Ripart M, Chari A, Tisdall M, Bargallo N, Conde-Blanco E, Pariente JC, Pascual-Diaz S, Delgado-Martínez I, Pérez-Enríquez C, Lagorio I, Abela E, Mullatti N, O'Muircheartaigh J, Vecchiato K, Liu Y, Caligiuri M, Sinclair B, Vivash L, Willard A, Kandasamy J, McLellan A, Sokol D, Semmelroch M, Kloster A, Opheim G, Yasuda C, Zhang K, Hamandi K, Barba C, Guerrini R, Gaillard WD, You X, Wang I, González-Ortiz S, Severino M, Striano P, Tortora D, Kalviainen R, Gambardella A, Labate A, Desmond P, Lui E, O'Brien T, Shetty J, Jackson G, Duncan JS, Winston GP, Pinborg L, Cendes F, Cross JH, Baldeweg T, Adler S (2022) 'Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study.' Epilepsia, 63 (1): 61-74. PMID: 34845719

Lacerda LM, Liasis A, Handley SE, Tisdall M, Cross JH, Vargha-Khadem F, Clark CA (2021) 'Mapping degeneration of the visual system in long-term follow-up after childhood hemispherectomy - A series of four cases.' Epilepsy Res, 178 (): 106808. PMID: 34801940

Zvi IB, Enright N, D'arco F, Tahir MZ, Chari A, Cross JH, Eltze C, Tisdall MM (2022) 'Children with seizures and radiological diagnosis of focal cortical dysplasia: can drug-resistant epilepsy be predicted earlier?' Epileptic Disord, 24 (1): 111-122. PMID: 34750096

Khan M, Paktiawal J, Piper RJ, Chari A, Tisdall MM (2022) 'Intracranial neuromodulation with deep brain stimulation and responsive neurostimulation in children with drug-resistant epilepsy: a systematic review.' J Neurosurg Pediatr, 29 (2): 208-217. PMID: 34678764

Castagno S, D'Arco F, Tahir MZ, Battey H, Eltze C, Moeller F, Tisdall M (2021) 'Seizure outcomes of large volume temporo-parieto-occipital and frontal surgery in children with drug-resistant epilepsy.' Epilepsy Res, 177 (): 106769. PMID: 34560348

Piper RJ, Tangwiriyasakul C, Shamshiri EA, Centeno M, He X, Richardson MP, Tisdall MM, Carmichael DW (2021) 'Functional Connectivity of the Anterior Nucleus of the Thalamus in Pediatric Focal Epilepsy.' Front Neurol, 12 (): 670881. PMID: 34408719

Roth J, Constantini S, Ekstein M, Weiner HL, Tripathi M, Chandra PS, Cossu M, Rizzi M, Bollo RJ, Machado HR, Santos MV, Keating RF, Oluigbo CO, Rutka JT, Drake JM, Jallo GI, Shimony N, Treiber JM, Consales A, Mangano FT, Wisoff JH, Teresa Hidalgo E, Bingaman WE, Gupta A, Erdemir G, Sundar SJ, Benifla M, Shapira V, Lam SK, Fallah A, Maniquis CAB, Tisdall M, Chari A, Cinalli G, Blount JP, Dorfmüller G, Christine Bulteau, Uliel-Sibony S (2021) 'Epilepsy surgery in infants up to 3 months of age: Safety, feasibility, and outcomes: A multicenter, multinational study.' Epilepsia, 62 (8): 1897-1906. PMID: 34128544

Li YF, Scerif F, Picker SR, Stone TJ, Pickles JC, Moulding DA, Avery A, Virasami A, Fairchild AR, Tisdall M, Harkness W, Cross JH, Hargrave D, Guillemot F, Paine SM, Yasin SA, Jacques TS (2021) 'Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis.' Neuropathol Appl Neurobiol, 47 (6): 781-795. PMID: 33797808

Vakharia VN, Diehl B, Tisdall M (2021) 'Visual field defects in temporal lobe epilepsy surgery.' Curr Opin Neurol, 34 (2): 188-196. PMID: 33664204

Chari A, Thornton RC, Tisdall MM, Scott RC (2020) 'Microelectrode recordings in human epilepsy: a case for clinical translation.' Brain Commun, 2 (2): fcaa082. PMID: 32954332

Wagstyl K, Adler S, Pimpel B, Chari A, Seunarine K, Lorio S, Thornton R, Baldeweg T, Tisdall M (2020) 'Planning stereoelectroencephalography using automated lesion detection: Retrospective feasibility study.' Epilepsia, 61 (7): 1406-1416. PMID: 32533794

Pearce K, Dixon L, D'Arco F, Pujar S, Das K, Tahir Z, Tisdall M, Mankad K (2020) 'Epilepsy surgery in children: what the radiologist needs to know.' Neuroradiology, 62 (9): 1061-1078. PMID: 32435887

Lacerda LM, Clayden JD, Handley SE, Winston GP, Kaden E, Tisdall M, Cross JH, Liasis A, Clark CA (2020) 'Microstructural Investigations of the Visual Pathways in Pediatric Epilepsy Neurosurgery: Insights From Multi-Shell Diffusion Magnetic Resonance Imaging.' Front Neurosci, 14 (): 269. PMID: 32322185

Kappen P, Eltze C, Tisdall M, Cross JH, Thornton R, Moeller F (2020) 'Stereo-EEG exploration in the insula/operculum in paediatric patients with refractory epilepsy.' Seizure, 78 (): 63-70. PMID: 32203882

Barba C, Cross JH, Braun K, Cossu M, Klotz KA, De Masi S, Perez Jiménez MA, Gaily E, Specchio N, Cabral P, Toulouse J, Dimova P, Battaglia D, Freri E, Consales A, Cesaroni E, Tarta-Arsene O, Gil-Nagel A, Mindruta I, Di Gennaro G, Giulioni M, Tisdall MM, Eltze C, Tahir MZ, Jansen F, van Rijen P, Sanders M, Tassi L, Francione S, Lo Russo G, Jacobs J, Bast T, Matta G, Budke M, Fournier Del Castillo C, Metsahonkala EL, Karppinen A, Ferreira JC, Minkin K, Marras CE, European Survey Group, Arzimanoglou A, Guerrini R (2020) 'Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation.' Epilepsia, 61 (2): 216-227. PMID: 31876960

Ferrand-Sorbets S, Fohlen M, Delalande O, Zuber K, Bulteau C, Levy M, Chamard P, Taussig D, Dorison N, Bekaert O, Tisdall M, Chipaux M, Dorfmüller G (2020) 'Seizure outcome and prognostic factors for surgical management of hypothalamic hamartomas in children.' Seizure, 75 (): 28-33. PMID: 31865135

Sa M, Singh R, Pujar S, D'Arco F, Desai N, Eltze C, Hughes E, Al Obaidi M, Eleftheriou D, Tisdall M, Selway R, Cross JH, Kaliakatsos M, Valentin A (2019) 'Centromedian thalamic nuclei deep brain stimulation and Anakinra treatment for FIRES - Two different outcomes.' Eur J Paediatr Neurol, 23 (5): 749-754. PMID: 31446001

Chipaux M, Taussig D, Dorfmuller G, Dorison N, Tisdall MM, Boyd SG, Thornton R, Eltze C, Fohlen M, Cross HJ, Ferrand-Sorbets S (2019) 'SEEG-guided radiofrequency thermocoagulation of epileptic foci in the paediatric population: Feasibility, safety and efficacy.' Seizure, 70 (): 63-70. PMID: 31288205

Corbet Burcher G, Liang H, Lancaster R, Cross JH, Tisdall M, Varadkar S, Spoudeas HA, Caredda E, Bennett S, Heyman I (2019) 'Neuropsychiatric profile of paediatric hypothalamic hamartoma: systematic review and case series.' Dev Med Child Neurol, 61 (12): 1377-1385. PMID: 30977116

Sharma JD, Seunarine KK, Tahir MZ, Tisdall MM (2019) 'Accuracy of robot-assisted versus optical frameless navigated stereoelectroencephalography electrode placement in children.' J Neurosurg Pediatr, 23 (3): 297-302. PMID: 30611155

Adler S, Blackwood M, Northam GB, Gunny R, Hong SJ, Bernhardt BC, Bernasconi A, Bernasconi N, Jacques T, Tisdall M, Carmichael DW, Cross JH, Baldeweg T (2018) 'Multimodal computational neocortical anatomy in pediatric hippocampal sclerosis.' Ann Clin Transl Neurol, 5 (10): 1200-1210. PMID: 30349855

Baud MO, Perneger T, Rácz A, Pensel MC, Elger C, Rydenhag B, Malmgren K, Cross JH, McKenna G, Tisdall M, Lamberink HJ, Rheims S, Ryvlin P, Isnard J, Mauguière F, Arzimanoglou A, Akkol S, Deniz K, Ozkara C, Lossius M, Rektor I, Kälviäinen R, Vanhatalo LM, Dimova P, Minkin K, Staack AM, Steinhoff BJ, Kalina A, Krsek P, Marusic P, Jordan Z, Fabo D, Carrette E, Boon P, Rocka S, Mameniškienė R, Vulliemoz S, Pittau F, Braun KPJ, Seeck M (2018) 'European trends in epilepsy surgery.' Neurology, 91 (2): e96-e106. PMID: 29898967

Vakharia VN, Sparks R, Rodionov R, Vos SB, Dorfer C, Miller J, Nilsson D, Tisdall M, Wolfsberger S, McEvoy AW, Miserocchi A, Winston GP, O'Keeffe AG, Ourselin S, Duncan JS (2018) 'Computer-assisted planning for the insertion of stereoelectroencephalography electrodes for the investigation of drug-resistant focal epilepsy: an external validation study.' J Neurosurg, 130 (2): 601-610. PMID: 29652234

De Blasi B, Barnes A, Galazzo IB, Hua CH, Shulkin B, Koepp M, Tisdall M (2018) 'Age-Specific (18)F-FDG Image Processing Pipelines and Analysis Are Essential for Individual Mapping of Seizure Foci in Pediatric Patients with Intractable Epilepsy.' J Nucl Med, 59 (10): 1590-1596. PMID: 29626122

Faramand AM, Barnes N, Harrison S, Gunny R, Jacques T, Tahir MZ, Varadkar SM, Cross HJ, Harkness W, Tisdall MM (2018) 'Seizure and cognitive outcomes after resection of glioneuronal tumors in children.' Epilepsia, 59 (1): 170-178. PMID: 29178251

Rasul FT, Bal J, Pereira EA, Tisdall M, Themistocleous M, Haliasos N (2017) 'Current Surgical Options for Patients with Epilepsy.' Curr Pharm Des, 23 (42): 6508-6523. PMID: 29086680

Stone TJ, Keeley A, Virasami A, Harkness W, Tisdall M, Izquierdo Delgado E, Gutteridge A, Brooks T, Kristiansen M, Chalker J, Wilkhu L, Mifsud W, Apps J, Thom M, Hubank M, Forshew T, Cross JH, Hargrave D, Ham J, Jacques TS (2018) 'Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.' Acta Neuropathol, 135 (1): 115-129. PMID: 29058119

Narizzano M, Arnulfo G, Ricci S, Toselli B, Tisdall M, Canessa A, Fato MM, Cardinale F (2017) 'SEEG assistant: a 3DSlicer extension to support epilepsy surgery.' BMC Bioinformatics, 18 (1): 124. PMID: 28231759

Graham D, Tisdall MM, Gill D (2016) 'Corpus callosotomy outcomes in pediatric patients: A systematic review.' Epilepsia, 57 (7): 1053-68. PMID: 27237542

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, Baio G, Trevisi G, Tisdall M, Ourselin S, McEvoy AW, Duncan J (2016) 'Comparison of computer-assisted planning and manual planning for depth electrode implantations in epilepsy.' J Neurosurg, 124 (6): 1820-8. PMID: 26636383

Papandreou A, Tisdall MM, Chong WK, Cross JH, Harkness WF, Varadkar SM (2014) 'COL4A1 mutations should not be a contraindication for epilepsy surgery.' Childs Nerv Syst, 30 (8): 1467-9. PMID: 24864020

Epilepsy care and research is a team sport and would not be possible without a huge range of clinicians and academics at Great Ormond Street Hospital UCL-GOS Institute of Child Health and beyond. We recognise the importance of this teamwork in maximising the impact of our research to ultimately care for children with epilepsy and therefore collaborate extensively with researchers and clinicians to help us realise our aims. Below you will find some photos of our team and links to the websites of some of our key collaborators.

Dr Konrad Wagstyl, Dr Sophie Adler & the MELD team

Prof Tim Denison & the Brain Networks Dynamics Unit

Dr Richard Rosch & the Dynamic Brains team

The GOSH Neurology, Neurophysiology & Neuroradiology Teams

Dr Amy McTague

Professor David Carmichael

Professor Rod Scott

Professor Chris Clark

Professor Helen Cross

Dr Peter Taylor, Dr Yujiang Wang & the CNNP lab

Prof Mehmet Fatih Yanik & ETH Zurich Neurotechnology Group

Flavia Matos Santo

PhD 2023-

The mosaic brain: a new diagnostic approach in focal epilepsies

Ulrich Stoof

PhD 2020-

Biophysical modelling of intracranial EEG

Jamie Norris

PhD 2021-

Modelling interictal brain states to guide stimulation in intracranial EEG

Michelle Ruiz-Perez

​Neurosurgery MRes 2024

Thalamic connectivity alterations in focal epilepsy 

Amy Williams

Neuroscience MSc 2024

Temporal volumetric changes in children with temporal lobe epilepsy

Margot Roeth

​Neuroimaging MRes 2023

Extent of resection and surgical outcomes in focal cortical dysplasia

Maria Eriksson

PhD 2023

Outcomes after neurosurgical treatment of paediatric epilepsy

Stasa Tumpa

iBSC 2021

Dynamic causal modelling of intracranial EEG in tuberous sclerosis

David Graham

Seizure outcomes after corpus callosotomy in children

Pierce Burr

Neuroscience MSc 2024

Longitudinal changes in focal cortical dysplasia lesions

Oliver Dennett

​Neurosurgery MRes 2023

Structural brain network & connectomic changes in hypothalamic hamartoma

Rachel Wilson-Jeffers

​Neurosurgery MRes 2023

Logitudinal structural brain network changes in focal epilepsy

Mehdi Khan

iBSC 2021

Extent of resection and surgical outcomes in children undergoing SEEG

Andrew Faramand

Neuroscience MSc 2016

Seizure and cognitive outcomes for glioneuronal tumours