Analysing immune responses to vaccination
Analysing humoral and cellular immune responses to vaccination during chronic infection
Project Summary
Studies of licensed vaccines such as the seasonal influenza virus vaccine present a valuable system to analyse post vaccine cellular and antibody responses. We are looking to recruit health care workers and HIV positive individuals who have not yet received their flu vaccine to investigate this further.
Who is eligible:
Individuals who are about to receive the flu vaccine and willing to give blood at three time points. These are: up to 30 days before their flu vaccination is administered, 7 days after, and 6 months after receiving the vaccine. We are also interested in recruiting HIV positive patients that meet the same criteria. Additionally, there will be a short questionnaire to complete at each visit.
Exclusion criteria:
Those co-infected with mycobacterium tuberculosis, Hepatitis B, Hepatitis C, Malaria. Also excluded are those with an AIDS Defining condition, undergoing concurrent cancer treatment, concurrent steroid treatment, pregnant or planning a pregnancy or with a previous allergic reaction to influenza vaccine/egg allergy.
If you are a potential participant in the study, you can contact a member of the study team to discuss joining the study – see Contact list on this page.
Key Project Information
Dates: October 2020 to October 2025
Status: Current
UCL lead/Principal Investigator: Dr Dimitra Peppa, Dr Richard Gilson and Dr Laura Waters
Lead organisation: Division of Infection and Immunity, University College London
Project lead: Dr Laura McCoy
Partners: Central and North West London NHS Foundation Trust; Division of Infection and Immunity, University College London
Location: UK
Funding: European Research Council Starting Grant: Understanding HIV-specific B cell function and viral immunogenicity (L E McCoy). National Institutes of Health (NIH) Cooperative agreement grant UM1 AI 00645: Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) (Persephone Borrow (overall grant PI Bart Haynes))
Contact: Rebecca Matthews (rebecca.matthews5@nhs.net), Paulina Prymas (paulina.prymas@nhs.net)
Dr Persephone Borrow
Dr Richard Gilson
Rebecca Matthews
Laura McCoy
Dr Dimitra Peppa
Paulina Prymas
Dr Laura Waters