Minireview: Tracking stem cells in tissue-engineered organs using magnetic nanoparticles
18 October 2013
Roxanne Hachani, Mark Lowdell, Martin Birchall, Nguyễn Thi Kim Thanh
The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and track SCs by magnetic resonance imaging (MRI) since this clinically available imaging modality has high spatial resolution. In this review, we highlight recent applications of iron oxide and gadolinium based MNPs in SC labelling and MRI; and offer novel considerations for their future development.
Abstract and image from Royal Society of Chemistry http://pubs.rsc.org/en/Content/ArticleLanding/2013/NR/C3NR03861K#!divAbstract