Close
The UCL School of Pharmacy NMR Facility has been designed for a wide range of solution-state pharmaceutical and biological chemistry applications.
Recently upgraded in 2022, the NMR facility is equipped with a 600 MHz magnet equipped with a high-throughput autosampler and QCI-F cryoprobe optimised for 1H and 19F sensitivity, and a 400 MHz magnet dedicated to routine chemistry applications. The facility also contains a liquid handling robot for NMR sample preparation, which is intended for use with our brand new ligand-observed 19F-fragment library screening service for drug discovery.
In addition to providing a routine NMR service, we are also interested in establishing collaborations with other academic institutions. Work for industries is subject to contract depending on the scale of work.
Instrumentation
Bruker Avance Neo 600 MHz NMR spectrometer
- QCI-F (19F, 1H, 13C, 15N) cryoprobe for increased 1H and 19F sensitivity
- Temperature range: -20° to 70° C
- SampleJet autosampler with cooled 96-well rack positions for 4-inch tubes and an outer carousel for handling standard 7-inch tubes
- Used for 1H/19F experiments, biomolecular experiments (2D, 3D assignment, structure determination, relaxation for proteins + nucleic acids), binding measurements (STD, waterLOGSY, transferred relaxation), diffusion and more
Bruker Avance Neo 400 MHz NMR spectrometer
- BBO iProbe for 1H + a range of X-nuclei including 19F, 31P, 13C, 15N, 11B
- Temperature range: Room temperature to 120° C
- 60-position SampleCase autosampler
- Rolling queue system using NOMAD management system for easy sample submission and data access
- Variety of standard experiments set up including 1H 1D spectra, 1H-decoupled 13C, 19F, and 31P 1D spectra, 19F-decoupled 1H 1D, 13C HSQC, NOESY, 1H and 31P diffusion ordered spectra, and water suppressed experiments.
Contact
Dr Nikita Harvey
NMR Facility Manager
Telephone: 020 3549 5193
nikita.harvey@ucl.ac.uk
Dr Christopher Waudby
Lecturer in Biomolecular NMR
waudbylab.org
c.waudby@ucl.ac.uk
