Marta Huelin Gorriz
Memory consolidation, the selective storage of information into long-term memory, is critical for our ability to learn and remember. In order to consolidate a memory, the brain is thought to use the process of replay, whereby neural activity patterns reflecting an awake experience are spontaneously reactivated outside of that experience (e.g. during sleep). Based on this, a current hypothesis postulates that memory consolidation depends on the bi-directional interaction between neocortex and hippocampus during NREM sleep, such that cortical activity initially directs which memories will be replayed by the hippocampus, while subsequent coordinated replay from hippocampus to cortex directs the storage of memory traces into cortical networks.
The purpose of my PhD is to investigate the role of cortico-hippocampal interactions underlying memory consolidation. By using large-scale electrophysiological recording methods combined with optogenetics, I will study the circuitry underlying the spatio-temporal flow of information between auditory cortex and hippocampus during replay.
26 Bedford Way