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Whole-brain fMRI mapping of neural activity recorded from a single voxel.

Whole-brain fMRI mapping of neural activity recorded from a single voxel.

Daniel Zavidar, National Institute of Mental Health

The temporal correlation of fMRI-fluctuations between two brain regions is often taken as a measure of functional-connectivity. However, individual neurons within a given region exhibit diverse and sometimes uncorrelated activity-patterns from their neighboring neurons, raising the question of how to interpret area-based fMRI correlations. By using simultaneous fMRI and electrophysiology in non-human primates we investigated how multiple, simultaneously recorded neural signals from a single-voxel map onto spontaneous fMRI-fluctuations elsewhere in the brain. I will show you how single-units within <1mm3 of cortical tissue participate in multiple anatomical-functional domains, even under conditions of minimal stimulation. This local functional diversity cannot be ascertained from either the local LFP or fMRI activity

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