NPP Logo

UCL Department of Neuroscience, Physiology and Pharmacology, Division of Biosciences, Faculty of Life Sciences

NPP academic/Fellowship/support staff or researcher/technician vacancies and PhD studentship opportunities are posted when available on the UCL HR website:- http://www.ucl.ac.uk/hr/jobs/index.php

I) 2 PhD places funded by the European Union’s Horizon 2020 available in Prof Tony Dickenson's lab.....deadline 25th March 2015

Project overview.
BonePain is the first European platform to promote frontline research, innovation and education within bone pain. Millions in Europe and beyond suffer from bone pain, which is a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. The BonePain network have participants from 5 European countries and encompasses 6 academic groups and 3 industries all committed to creating an outstanding training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines.

1) Central consequences of cancer-induced bone pain.
You will be performing in vivo electrophysiological recordings in the spinal cord and brain under full general anaesthesia. The studies aim to look at coding of sensory information from the bone and adjacent tissues, looking at central sensitization and dissecting out the role of pharmacological systems in the responses. In addition, in collaboration with Dr Amy Fisher at Transpharmation you will study the behavioural processing of sensory events in the model. Here, assessment of pain-related behaviors will be performed by monitoring naturalistic (non-evoked) end-points. The duration and frequency of many additional multi-faceted behavioural parameters will be measured using LABORAS™ (Laboratory Animal Behaviour Observation Registration & Analysis System). Thus the project aims to link behaviour with neuronal events. lEnquiry.aspx?fapjid

2) Ion channels in osteoarthritis (OA).
For this position you will work on a rodent model of OA. There is much interest in novel ion channel modulators in pain, but little is known about their roles in OA. Here the aim would be to study how peripheral and central ion channels shape neuronal responses in the spinal cord and brain. The project will study how joint inputs are processed at various levels of the CNS and how deep tissue inputs are dealt with, in comparison to cutaneous signals. The contribution of neuropathic changes to the OA state will also be looked at.


The projects are funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642720

Supervision: Dept of Neuroscience, Physiology and Pharmacology, University College London, UK. The principal supervisor will be Professor Tony Dickenson, email: anthony.dickenson@ucl.ac.uk, direct phone +44 207 679 3742. http://www.ucl.ac.uk/npp/research/ahd

Required qualifications
The successful candidate must hold a relevant BSc or MSc degree. Experience with in vivo models, biology or chronic pain research will be an advantage. Solid level of English and good general communication skills are an advantage.

The position is available for a three-year period.

The candidate needs to be in the first four years of her/his research career. The four years are counted from the date the degree was obtained which formally entitles to embark on a doctorate.

How to apply
Informal enquiries to: Prof Tony Dickenson (anthony.dickenson@ucl.ac.uk)
Application procedure: Letter stating the interest in and qualifications for the project (max. one page) and a C.V. to anthony.dickenson@ucl.ac.uk

Eligibility: If the applicant has worked or studied in the UK for more than 12 months in the past 3 years the applicant is not eligible to apply.

Closing date: 25 March 2015

Shortlisted candidates only will be notified by e-mail

Funding Notes:

The candidate must not have resided or carried out his/her main activity (work, studies, etc.) in UK for more than 12 months in the last 3 years immediately prior to the start date.

The successful candidates will receive a stipend (this is not taxed) in accordance with the MSCA regulations for early stage researchers. Exact stipend will be confirmed upon appointment. Living Allowance = 37.320 euro/year (correction factor to be applied per country) + Monthly mobility allowance = 600 to 1100 Euro depending on the family situation

II) Apply for this PhD opportunity by 12pm Friday 6th March 2015:

The Francis Crick Institute has seven PhD projects currently open for application for the academic year 2015/16.

The Francis Crick Institute's PhD programme presents a fabulous opportunity for highly motivated and exceptionally talented individuals to embark on their career in biomedical research. The projects will be based at Mill Hill, at the National Institute for Medical Research, in the first instance and transfer to the Francis Crick Institute with their research groups in early 2016.

Details of the projects that we have open an instructions on how to apply can be found at http://www.nimr.mrc.ac.uk/phd/ Information on funding and eligibility can be found here http://www.nimr.mrc.ac.uk/phd/funding-and-eligibility/.


The deadline for submission of applications is 12pm, Friday 6th March 2015