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Leading the world on dementia
11 December 2013
The Prime Minister today called for a global effort to tackle one of the greatest challenges of our time: dementia.
UCL scientists, working with clinicians at the university's partner hospitals, are at the heart of the battle to treat the condition.
The UK is using its presidency of the G8 to spearhead a global effort to tackle dementia.
To
better understand the challenges that lie ahead, the Secretary of State
for Health Jeremy Hunt recently visited a hub of scientists and
clinicians leading dementia research projects.
Mr
Hunt was given a tour of facilities at the UCL Institute of
Neurology and the National Hospital for
Neurology and Neurosurgery (NHNN), part of University College London Hospitals NHS Foundation Trust.
The NHNN and neuroscientists based at UCL are at the
research epicentre. Clinical researchers are faced with several
challenges: they must develop new treatments to prevent, slow or stop
the disease - and identify as early as possible those who will benefit
from these treatments - and improve the treatment and care of those
affected now.
Mr Hunt observed ongoing research designed to
better understand the causes of dementia and changes to the brain and
met scientists working on understanding the molecular basis of
Alzheimer's disease and other forms of dementia using stem cells as a
model.
Mr Hunt examined at first hand the brains of people who
had dementia in life and observed the damage caused to brain cells. He
saw the effects of Alzheimer's disease on the brain including the
dramatically reduced hippocampus - a key structure that underpins our
memory functions.
He then visited the Dementia Research Centre, where he observed a routine
assessment of memory, language, perceptual and other cognitive skills
which relate directly to the progressive changes in the brain. Mr Hunt
then saw how MRI brain scans can detect early change and track the
progression of disease.
With an ageing population, dementia is
soon to become the biggest burden on healthcare systems around the
world. In 2010, the global cost of dementia was around £400 billion and
this figure will continues to rise as more people are diagnosed each
year. Alzheimer's Disease International estimates that about 135 million
people will be living with dementia by 2050.
The Prime Minister
is urging industrialised nations to come together to address the
problem head on. Today (11 December), London is hosting an international
G8 summit meeting on dementia. Health and science ministers,
world-leading experts and senior industry figures will come together to
identify and agree on a new international approach for future dementia
research.
The event hopes to secure a more coordinated and
collaborative approach to the development of new dementia treatments and
therapies.
Professor Nick Fox (UCL Institute of Neurology) whose
research involves improving diagnosis and tracking the very earliest
stages of the diseases said: "We desperately need to find better
treatment for these devastating diseases - and at the same time we must
improve the care and support for the growing numbers of families that
will be affected."
Up to 400 new dementia patients are referred to the NHNN each year, many are in their 50s and 60s and some even younger.
Professor Martin Rossor is director of the National Institute for Health Research (NIHR) dementia and neurodegenerative research network (DeNDRoN) which is hosted at UCL.
He said: "Research into dementia requires investment across the whole spectrum from basic science to policy research. The research groups at the NHNN and the UCL Institute of Neurology are particularly focused on early phase research and experimental medicine. Research at the NHNN and UCL covers the whole spectrum from basic science to health service research.
"We were pleased to welcome the health secretary to tell him more about our work."
The
NHNN and UCL have benefited from considerable funding grants in the
past 12 months which will accelerate the development of treatments and
identify future therapeutic targets for neurodegenerative diseases, with
the aim of earlier intervention for patients.
Image: Professor Nick Fox (left) and Dr Selina Wray with health
secretary Jeremy Hunt at the UCL Institute of Neurology. Dr Wray is
researching the molecular basis of Alzheimer's Disease and other forms
of dementia using stem cells as a model.
Text: UCLH Communications Unit
Links:
G8 Dementia Summit
UCL Institute of Neurology
UCL Neuroscience
National Hospital for Neurology and Neurosurgery
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