Fat Fraction Map

Neuromuscular MRI Research Group

The Neuromuscular MRI Research Group is part of the MRC Centre for Neuromuscular Diseases in the UCL Institute of Neurology and comprises MRI Physicists, Clinical Neurologists and Neuroradiolgists.

We work with partners across UCL, at Newcastle University, and in industry to develop advanced MRI techniques targeting muscle and peripheral nerve. Our aim is to provide imaging measures of disease severity which may be translated rapidly into clinical application for the benefit of patients with muscle wasting diseases.

Quantitative MRI

We are engaged in research to both optimise existing quantitative MRI methods for muscle and nerve applications and to develop novel approaches. Techniques under investigation include fat-fraction imaging, tissue-water relaxation time mapping, magnetization transfer imaging and diffusion imaging. These methods compliment our existing program of conventional MRI and high-resolution anatomical imaging in neuromuscular conditions.

MR Imaging and Clinical Facilities

The Neuromuscular MRI Research Group has access to state-of-the art imaging and clinical facilities including several 3 Tesla MRI research scanners and a clinical trials gym equipped with advanced quantitative muscle testing apparatus. We also benefit from collaborations with colleagues expert in neurophysiology, ophthalmology and medical computing.

Neuromuscular MRI Patient Studies

We are engaged in a number of important patient MRI studies under the framework of the MRC Centre for Neuromuscular Diseases and the National Hospital for Neurology and Neurosurgery, Queen Square as well as national and international collaborations. We work extensively with patients with inflammatory myopathies, peripheral neuropathies, muscular dystrophies and mitochondrial disease among other conditions.