Understanding the immune mechanisms underlying development of allograft vasculopathy and chronic rejection in solid organ transplantation.
Centre Lead - Mr Reza Motallebzadeh
Areas of Focus
- Delineating the role of the host microbiota in renal transplantation.
- Understanding the immune mechanisms underlying development of allograft vasculopathy and chronic rejection in solid organ transplantation, in particular the role of T follicular helper cells.
- Developing 3D renal organoids to study renal fibrosis
Description of research
Basic Science & Translational
- Integrating immunological, metabolite and microbiome data to predict clinical outcomes in kidney transplantation.
- Collaborators – Dr Bajaj-Elliot (GOS Institute of Child Heath, UCL), Dr Pesenacker (Institute of Immunity & Transplantation, UCL), Dr Jonathan Swann (Division of Integrative Systems Medicine and Digestive Diseases, Imperial College London), Dr Mark Harber, Professor Alan Salama & Dr Jennifer Rohn (Department of Renal Medicine, UCL)
- Outline - The composition of the microbiota and their metabolites could elicit signals that promote either an enhanced or diminished immune response against a kidney transplant. We aim to develop a better understanding of the changes to the gut microbiota and metabolites produced by them that can predict the course and heterogeneity of alloimmune responses.
- Human kidney extracellular matrix hydrogels as a natural 3D platform for bioengineered models of kidney fibrosis
- Collaborators – Professor Norman (UCL Centre for Experimental Nephrology), Dr Mazza (Institute of Liver & Digestive Health), Dr Twomey (UCB Pharma)
- Outline - The aim of this work is to develop, characterize, and validate a novel in vitro 3D human kidney organoid culture system ultimately aimed at screening for compounds capable of modulating the tubulointerstitial microenvironment crosstalk that perpetuates development of fibrosis in chronic kidney disease.
- Development of a point-of-care assay for monitoring rejection after renal transplantation.
- Collaborators – Professor Tiwari & Professor Balabani (Dept of Mechanical Engineering, UCL), Dr Mark Harber (Department of Renal Medicine, UCL)
- Outline – Development of a novel point-of-care device to monitor urinary chemokines serially in renal transplant recipients and identify recipients with incipient allograft injury. Immune-based biomarkers offer the potential for identifying patients at risk for graft rejection and for individualizing immunosuppression therapy.
- Surveillance of arteriovenous fistulae using ultrasound (SONAR study)
- A prospective multi-centre observational cohort study to determine whether ultrasound surveillance can reliably predict arteriovenous fistulae failure in patients with chronic kidney disease
- Anaesthesia Choice for Creation of ArtEriovenous FiStulae (ACCESs study)
- A randomised controlled trial comparing clinical (one-year functional patency rate) and cost-effectiveness of regional versus local anaesthesia for primary arteriovenous fistula formation
- Pre-Implantation trial of Histopathology In renal Allografts (PITHIA study)
- An open, stepped-wedge cluster, randomised trial to determine if the introduction of a national pre-implantation biopsy histopathology service increases numbers, and improve outcomes, of kidney transplants performed in the UK.
Dr Amber Gintare Vaitkute – Post-doctoral research fellow (2020)
Fernando Yuen Chang – PhD Student (2020)
Lucia Marinas del Rey – PhD Student (to start Sept 2020)