Animal Models

As in humans, animals can also develop NCL. NCL that occurs naturally has been described in many species including dogs, cats, sheep, cattle, pigs, mice and birds. It is also possible to introduce genetic changes to create animals with NCL, especially mice and fish, but also larger animals such as pigs and sheep.

These animals are mostly being studied to understand more about disease progression, and in preclinical trials to test the effectiveness of new therapies and safety of vectors befor their use in clincial trials. Others may be used to identify new NCL genes that will help to complete the picture in terms of the genetic causes of NCL. Some genes that cause disease in animals may not have been found to cause disease in human patients.

DNA tests may be available to identify carrier animals. Careful breeding can prevent the disease being passed to any offspring.



Non-human primate