UCL Medical Physics and Bioengineering
- General teaching pages
- Adam's homepage
- Jem's Homepage
- Prospective Students
- UCLH Department
- Careers in Medical Physics and Bioengineering
- International Links
- Optical Topography
- How to Apply
- Open Day
- 4D neonatal head model
Search Medical Physics
UCL Centre for Space Medicine
4D neonatal head model
Diffuse optical imaging methods require accurate knowledge of the anatomy of the brain and head in order to make optimal use of the spatial information contained in the data. Where the MRI of the individual subject or patient is unavailable, the best-practice approach is to use a suitable generic head atlas. Although diffuse optical methods have a long history of application to infants, there is no standard atlas model that provides the necessary, age-matched models of the brain and extra-cerebral tissues for pre-term and term age infants that are necessary for accurate use of diffuse optical imaging approaches.
In collaboration with researchers at King's College London, we have taken the MRI atlas described by Kuklisova-Murgasova et al. to produce a 4D neonatal head model for diffuse optical imaging. The model is based on spatially averaged and segmented MRI data from 324 infants (160 female) between the ages of 29 and 44 weeks (gestational).
The infant head models available below will soon be incorporated into the HOMER2 fNIRS processing package.
The 4D Neonatal Head Model Package
The package available below contains the following components (in .txt and .mat Matlab(R) formats) for every age from 29 to 44 weeks gestation age in 1-week intervals:
The voxel space tissue mask. Each voxel is assigned an index which defines tissue type.
A text file which links each segmented tissue type to its index value (this is the same for all ages).
The whole-head tetrahedral volume mesh. Each element is assigned an index which defines tissue type (this is the 5th column of the associated matlab field HeadVolumeMesh_#weeks.elem).
The surface mesh of the external surface of the extra-cerebral tissue layer.
The surface mesh of the external surface of the grey matter tissue layer.
The surface mesh of the external surface of the white matter tissue layer.
The 3D locations of the Inion, Nasion, Ar and Al cranial landmarks. These points were defined on the tetrahedral volume mesh and correspond to particular nodes in that mesh.
The 3D positions of 10-5 locations defined on the tetrahedral volume mesh. Includes the vertex, Cz.
The 4D neonatal head model (which totals 1.0 Gb) can be downloaded from here.
For any questions relating to the download and use of this package please contact Dr. Rob Cooper at email@example.com.
Brigadoi et al., 2013: A 4D neonatal head model for diffuse optical imaging of pre-term to term infants. In review.