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Department of Inflammation
Our work
Research activities focused on inflammation conditions, including amyloidosis and rheumatology, are burgeoning areas in medical science.
For amyloidosis, investigations aim to understand the abnormal accumulation of misfolded proteins leading to organ damage. We explore the novel diagnostic tools, therapeutic interventions, and molecular pathways involved in amyloid formation. We work towards targeted treatments that address the root causes of this disorder, enhancing patient outcomes.
In rheumatology, the emphasis is on unravelling the complexities of autoimmune and inflammatory diseases affecting the joints and connective tissues. Advances in genomics, immunology, and precision medicine contribute to personalized therapies for conditions like rheumatoid arthritis and lupus.
We collaborate across disciplines to improve our understanding of inflammatory mechanisms, driving towards breakthroughs to improve diagnostics and therapeutic strategies for patients grappling with these challenging conditions.
Our centres
- Centre for Amyloidosis and Acute Phase Proteins
The Centre for Amyloidosis and Acute Phase Proteins comprises the NHS National Amyloidosis Centre, funded by the Department of Health, to provide diagnostic and management advisory services for the national caseload of patients with amyloidosis and hereditary periodic fever syndromes, and the Wolfson Drug Discovery Unit.
Head of Centre
- Professor Julian Gillmore
- Professor Marianna Fontana (Deputy)
Principal Investigators
- Professor Vittorio Bellotti
- Professor Philip Hawkins
- Professor Helen Lachmann
- Professor Sir Mark Pepys
- Professor Paul Simons
- Professor Ashutosh Wechalekar
Associated research themes
- Centre for Rheumatology and Bloomsbury Rheumatology Unit
Connective tissue diseases are a spectrum of disorders characterised by inflammation, tissue damage and remodelling or excessive repair often leading to destruction and degeneration of the target organ and replacement with scar or fibrotic tissue.
Heads of Centre
- Professor David Abraham
- Professor Christopher Denton
Principal Investigators
- Professor David Isenberg
- Professor Jo Cambridge
- Dr Coziana Ciurtin
- Professor Michael Ehrenstein
- Professor Ian Giles
- Professor Elizabeth Jury
- Professor Anisur Rahman
- Dr Pedro Machado
- Dr Venkat Reddy
- Dr Maria Leandro
Associated research themes
- Centre of Metabolism and Inflammation
The Centre of Metabolism and Inflammation aims to investigate diagnostics and therapeutics for Non-Communicable Diseases
Heads of Centre
- Professor Mohammed Al Maadheed
- Professor Vidya Mohamed-Ali
Associated research themes