DoM Seminar: Professor Anne Barton

'Predicting response to therapies in rheumatoid arthritis: challenges and progress'

Professor Anne Barton
Professor of Rheumatology, Arthritis Research UK Centre for Genetics and Genomics.
Lead, Centre for Musculoskeletal Research.
Honorary Consultant in Rheumatology at Central Manchester Foundation Trust.
Research Lead for the Inflammatory arthritis in adults research theme of the NIHR Manchester Musculoskeletal Biomedical Research Unit.
University of Manchester

Host: Madhura Castelino
Department for Inflammation

Thursday 19th January 2022 at 13:00 -14:00
This seminar will take place in Second Floor Seminar Room of the Rayne Buiding and will also run on Teams (link)
Lunch will be provided

I joined the Arthritis Research UK Epidemiology Unit  in 1998 after being introduced to the field of Genetics of Complex disease when I undertook a laboratory-based research project as part of my MSc in Clinical Rheumatology, in 1997. By this time, I had developed a real enthusiasm for research and subsequently applied for and was awarded a MRC Clinical Training Fellowship. I undertook linkage and association analysis in RA families homologous to those identified in animal models of arthritis. This novel approach led to the identification of a region on chromosome 17q as a potential rheumatoid arthritis (RA) disease locus. The results of this work formed the foundation for my successful Wellcome Trust Advanced Fellowship application, which was awarded in May 2003 and extended for one year in May 2006. 

Since completion of my Wellcome Trust Advanced Fellowship, I have been involved in the Wellcome Trust Case Control Consortium study to perform a genome-wide investigation for 7 common diseases, including rheumatoid arthritis, which was published in Nature. Excitingly, a novel rheumatoid arthritis susceptibility locus was detected and confirmed in replication studies leading to a further high-profile publication. Work is underway to identify the causal variant and determine how it contributes to disease.

I have a program of work in pharmacogenetics, particulalry in predicting response to treatment in patients receiving biologic therapies for their arthritic diseases. I have established the Biologics in RA Genetics and Genomics Study Syndicate (BRAGGSS), comprising the rheumatologists at the larger prescribing centres across the UK, and co-ordinate the collection of DNA samples from patients treated with these agents at these centres. The collection is now by far the largest in the world (approximately 4,000 patients with DNA and >1,000 with additional samples, e.g. RNA) and represents a unique resource because of the richness of the phenotypic data available.

I have a strong interest in the genetic presdisposition to psoriatic arthritis, the second most common of the inflammatory arthritic diseases. I lead a UK consortium trying to identify susceptibility genes and I chair the PAGE (Psoriatic Arthritis Genetic European) consortium to establish a European-wide collaboration to take this field of research forward.

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The seminars are open to UCL & UCLH staff, students and their visitors. Please contact alison.kelly@ucl.ac.uk for all enquires  
Audience members: Please ensure that your mic is muted and video turned off during the talk. There will be a 10-minute Q&A at the end of the talk. Please ensure that you use the ‘raise hand’ function if you would like to ask a question. Thank you.