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Study shows potential of gene-editing liver resident T cells to treat hepatic tumors

A recent study by the Maini group shows the potential of gene-editing liver resident T cells to treat hepatic tumors and viral infections.

27 November 2018

Hepatitis B virions with Dane particles

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  • Faculty of Medical Sciences
  • Study shows potential of gene-editing liver resident T cells to treat hepatic tumors

Work on the paper, ‘Molecular recalibration of PD-1+ antigen-specific T cells from blood and liver’, was carried out by Itziar Otano who joined the Maini lab from Universidad de Navarra in Pamplona, Spain to work as a post-doc, funded by EASL and the Wellcome Trust.

For the final part of this project, Itziar worked in the labs of Andrea Pavesi and Antonio Bertoletti in Singapore to test genetically engineered T cells in their 3D microfluidic model of HBV-related liver cancer.

Links

  • Read the paper: Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver (Molecular Therapy Journal)
  • Profile: Professor Mala Maini
  • Website: Maini Group

Image

  • Credit: ‘Hepatitis B virions with Dane particles’, Dr Erskine Palmer, CDC via Flickr

Highlights in Medical Sciences

Drug to treat aggressive leukaemia approved for use in adults
Fluorescence microscopy image of immune cells, showing blue-stained nuclei surrounded by green cell membranes with red marker signals indicating specific proteins or activity within the cells.

Research

Drug to treat aggressive leukaemia approved for use in adults

Adult patients with aggressive leukaemia will soon be able to receive a breakthrough immunotherapy, developed by UCL researchers, on the NHS after approval by NICE.

Millions could benefit from faster prostate cancer scan
healthy prostate scan

Research

Millions could benefit from faster prostate cancer scan

Results of the PRIME trial involving UCL Medical Sciences researchers have found that a quicker, cheaper MRI scan was just as accurate at diagnosing prostate cancer as the current 30-40 minute scan.

10 September 2025

UCL Cancer Institute awarded Athena SWAN Gold
Athena Swan Gold Award

Award

UCL Cancer Institute awarded Athena SWAN Gold

The UCL Cancer Institute has been awarded Athena SWAN Gold in recognition of its sustained commitment to advancing gender equality in higher education and research.

20 May 2025

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