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Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair

Bhangra K S, Busuttil F, Phillips J B, Rahim A A.

26 April 2016

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Stem Cells International

Peripheral nerve injury continues to pose a clinical hurdle despite its frequency and advances in treatment. Unlike the central nervous system, neurons of the peripheral nervous system have a greater ability to regenerate. However, due to a number of confounding factors, this is often both incomplete and inadequate. The lack of supportive Schwann cells or their inability to maintain a regenerative phenotype is a major factor.

Advances in nervous system tissue engineering technology have led to efforts to build Schwann cell scaffolds to overcome this and enhance the regenerative capacity of neurons following injury. Stem cells that can differentiate along a neural lineage represent an essential resource and starting material for this process. In this review, we discuss the different stem cell types that are showing promise for nervous system tissue engineering in the context of peripheral nerve injury. We also discuss some of the biological, practical, ethical, and commercial considerations in using these different stem cells for future clinical applications.

Read the full paper

Highlights in Medical Sciences

New Dean of Medical Sciences appointed
Professor Emma Morris

Announcement

New Dean of Medical Sciences appointed

Internationally recognised clinician scientist, Professor Emma Morris, will take up the role of Dean of UCL's Faculty of Medical Sciences in August 2025.

28 February 2025

Lung cancer test better predicts survival in early stages of disease
Cancer Cells Dividing

Research breakthrough

Lung cancer test better predicts survival in early stages of disease

A new test developed by UCL Cancer Institute and the Francis Crick Institute can better predict lung cancer survival at diagnosis.

09 January 2025

The King and Queen meet UCL cancer specialists at UCLH
Professor Charles Swanton (left) and Professor Karl Peggs (right) meet with The King and Queen

Royal visits

The King and Queen meet UCL cancer specialists at UCLH

King Charles and Queen Camilla met UCL clinical researchers developing new cancer treatments, along with cancer patients receiving care and their families.

01 May 2024

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