Amyloid Fibril Typing - Histology and Proteomic Analysis
Accurate identification of the amyloid fibril protein is the critical first step in the diagnostic pathway for any patient with amyloidosis.
Our Jack O'Neill Laboratory performs Congo red staining to confirm amyloid deposits
Amyloid fibril typing is done by a panel of specialised antibodies to a variety of amyloid fibril proteins using immunohistochemical methods optimised for amyloid fibril typing.
In cases where the immunohistochemistry is not decisive or additional information is considered useful for clinical or diagnostic purposes, samples are further analysed by laser.
We capture the amyloid deposits and subject them to mass spectrometry (LCMS), a sophisticated and highly accurate approach to determine the amyloid fibril type.
Questions
For any questions regarding histology or proteomic analysis please contact:
Clinical Advice
Any clinical advice about amyloid typing must be discussed with one of our consultant staff:
Professor Julian Gillmore
Click to email. julian.gillmore@nhs.net
Professor Helen Lachmann
Click to email. helen.lachmann@nhs.net
Professor Ashutosh Wechalekar
Click to email. awechalekar@nhs.net
