Journal Club

Next Journal Club - 20 March

Nat Ageing 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Julio Aguado, Alberto A Amarilla, Atefeh Taherian Fard, Eduardo A Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman K Chaggar, Naphak Modhiran, Cecilia Gómez-Inclán, Ibrahim Javed, Alireza A Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, Pranesh Padmanabhan, Morgan E Freney, Rhys Parry, Julian D J Sng, Ariel Isaacs, Alexander A Khromykh, Guillermo Valenzuela Nieto, Alejandro Rojas-Fernandez, Thomas P Davis, Marco Prinz, Bertram Bengsch, Vadim N Gladyshev, Trent M Woodruff, Jessica C Mar, Daniel Watterson, Ernst J Wolvetang.

Previous weeks papers

Nat Commun 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1 Yanxia Huang, Qinyu Peng, Xu Tian, Cancan Chen, Xuanfeng Zhu, Changbai Huang, Zhiting Huo, Yang Liu, Chao Yang, Chao Liu, Ping Zhang

Proc Nail Acad Sci USA. 2023 Nov 28;120(48):e2306374120. doi: 10.1073/pnas.2306374120. Epub 2023 Nov 20. The cyclophilin A-binding loop of the capsid regulates the human TRIM5α sensitivity of nonpandemic HIV-1 Augustin P Twizerimana, Daniel Becker, Shenglin Zhu, Tom Luedde, Holger Gohlke, Carsten Münk

Immunity. 2023 Nov 14;56(11):2492-2507.e10. doi: 10.1016/j.immuni.2023.10.001. Epub 2023 Oct 26. SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Yanfei Hou, Zhimeng Wang, Peiyuan Liu, Xubiao Wei, Zhengyin Zhang, Shilong Fan, Lulu Zhang, Fangping Han, Yikang Song, Ling Chu, Conggang Zhang

Cell Rep. 2023 Jan 31;42(1):112016. doi: 10.1016/j.celrep.2023.112016. Epub 2023 Jan 19. RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer. Hong-Tao Li, H Josh Jang, Krizia Rohena-Rivera, Minmin Liu, Hemant Gujar, Justin Kulchycki, Shuqing Zhao, Sandrin Billet, Xinyi Zhou, Daniel J Weisenberger, Inderbir Gill, Peter A Jones, Neil A Bhowmick, Gangning Liang

Cell 2023 May 11;186(10):2144-2159.e22. doi: 10.1016/j.cell.2023.03.036. Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases. Matae Ahn, Vivian Chih-Wei Chen, Pritisha Rozario, Wei Lun Ng, Pui San Kong, Wan Rong Sia, Adrian Eng Zheng Kang, Qi Su, Lan Huong Nguyen, Feng Zhu, Wharton O Y Chan, Chee Wah Tan, Wan Shoo Cheong, Ying Ying Hey, Randy Foo, Fusheng Guo, Yan Ting Lim, Xin Li, Wan Ni Chia, Radoslaw M Sobota, Nai Yang Fu, Aaron T Irving, Lin-Fa Wang

Nat Microbiol 2023 Nov;8(11):2115-2129. doi: 10.1038/s41564-023-01501-z. Epub 2023 Oct 9. Antiviral responses are shaped by heterogeneity in viral replication dynamics. Lucas J M Bruurs, Micha Müller, Jelle G Schipper, Huib H Rabouw, Sanne Boersma, Frank J M van Kuppeveld, Marvin E Tanenbaum.

Nature 2023 Aug;620(7975):873-880. doi: 10.1038/s41586-023-06401-0. Epub 2023 Aug 9. TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6, Yiqi Zhao, Yongxu Lu, Samuel Richardson, Meghna Sreekumar, Jonas D Albarnaz, Geoffrey L Smith

Nat Immunol. 2022 Sep;23(9):1379-1392. doi: 10.1038/s41590-022-01290-3. Epub 2022 Aug 24. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B. Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti, Francesco Guidi, Francesca Sperati, Sara Vitale, Daniele Macchia, Massimo Spada, Giovanna Schiavoni, Fabrizio Mattei, Adele De Ninno, Luca Businaro, Valeria Lucarini, Laura Bracci, Eleonora Aricò, Giovanna Ziccheddu, Francesco Facchiano, Stefania Rossi, Massimo Sanchez, Alessandra Boe, Mauro Biffoni, Ruggero De Maria, Ilio Vitale, Antonella Sistigu

J Phys Chem B. 2021 Mar 18;125(10):2513-2520. doi: 10.1021/acs.jpcb.0c11068. Epub 2021 Mar 5. Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility. Maria I Freiberger, Peter G Wolynes, Diego U Ferreiro, Monika Fuxreiter

Nature 2023 Apr;616(7957):563-573. doi: 10.1038/s41586-023-05771-9. Epub 2023 Apr 12. Antibodies against endogenous retroviruses promote lung cancer immunotherapy Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T C Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Thomas B K Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M Frankell, Maise Al Bakir, Emilia L Lim, Mark S Hill, Gareth A Wilson, Daniel E Cook, Nicolai J Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw; TRACERx Consortium; CAPTURE Consortium; Crispin T Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward, George Kassiotis

Nature 2023 Jun 23. doi: 10.1038/s41586-023-06343-7. Online ahead of print. Author Correction: A viral biomolecular condensate coordinates assembly of progeny particles. Matthew Charman, Nicholas Grams, Namrata Kumar, Edwin Halko, Joseph M Dybas, Amber Abbott, Krystal K Lum, Daniel Blumenthal, Elene Tsopurashvili, Matthew D Weitzman

Embo J. 2023 Mar 27;e112234. doi: 10.15252/embj.2022112234. Online ahead of print. Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity. Giulia Unali, Giovanni Crivicich, Isabel Pagani, Monah Abou-Alezz, Filippo Folchini, Erika Valeri, Vittoria Matafora, Julie A Reisz, Anna Maria Sole Giordano, Ivan Cuccovillo, Giacomo M Butta, Lorena Donnici, Angelo D'Alessandro, Raffaele De Francesco, Lara Manganaro, Davide Cittaro, Ivan Merelli, Carolina Petrillo, Angela Bachi, Elisa Vicenzi, Anna Kajaste-Rudnitski.

Nat Struct Mol Bio. 2023 Mar;30(3):370-382. doi: 10.1038/s41594-022-00887-4. Epub 2023 Jan 9. HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nadine Renner, Alex Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Böcking, Adolfo Saiardi, Eric O Freed, Leo C James

Nat Commun. 2023 Feb 6;14(1):634. doi: 10.1038/s41467-023-36364-9. Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes. Mayank N K Choudhary, Kara Quaid, Xiaoyun Xing, Heather Schmidt, Ting Wang

Sci Immunol. 2023 Jan 20;8(79):eabp9765. doi: 10.1126/sciimmunol.abp9765. Epub 2023 Jan 20. Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases. Kenta Mosallanejad, Stephanie N Kennedy, Kristin M Bahleda, Kailey M Slavik, Wen Zhou, Apurva A Govande, Dustin C Hancks, Philip J Kranzusch, Jonathan C Kagan

Cell, 2023 Jan 6;S0092-8674(22)01530-6. doi: 10.1016/j.cell.2022.12.017. Online ahead of print. 'Resurrection of endogenous retroviruses during aging reinforces senescence' Xiaoqian Liu, Zunpeng Liu, Zeming Wu, Jie Ren, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Cell Rep. 2022 Mar 15;38(11):110513. doi: 10.1016/j.celrep.2022.110513. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A. Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu, Lei Sun

mbio. 2022 Oct 26;13(5):e0180422. doi: 10.1128/mbio.01804-22. Epub 2022 Oct 3. Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Stephanie M Bester, Daniel Adu-Ampratwum  Arun S Annamalai, Guochao Wei, Lorenzo Briganti, Bridget C Murphy, Reed Haney, James R Fuchs, Mamuka Kvaratskhelia

Science. 2022 Jun 10;376(6598):eabm9506. doi: 10.1126/science.abm9506. Epub 2022 Jun 10. AI-based structure prediction empowers integrative structural analysis of human nuclear pores Shyamal Mosalaganti, Agnieszka Obarska-Kosinska, Marc Siggel, Reiya Taniguchi, Beata Turoňová, Christian E Zimmerli, Katarzyna Buczak, Florian H Schmidt, Erica Margiotta, Marie-Therese Mackmull, Wim J H Hagen, Gerhard Hummer, Jan Kosinski, Martin Beck

Cell Host Microbe. 2022 Mar 9;30(3):357-372.e11. doi: 10.1016/j.chom.2022.01.014. Epub 2022 Feb 18. Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Callum Talbot-Cooper, Teodors Pantelejevs, John P Shannon, Christian R Cherry, Marcus T Au, Marko Hyvönen, Heather D Hickman, Geoffrey L Smith

iScience. 2022 Jun 11;25(7):104599. doi: 10.1016/j.isci.2022.104599. eCollection 2022 Jul 15. Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1 Nicolas Vabret, Valérie Najburg , Alexander Solovyov, Ramya Gopal, Christopher McClain, Petr Šulc, Sreekumar Balan, Yannis Rahou, Guillaume Beauclair, Maxime Chazal, Hugo Varet, Rachel Legendre, Odile Sismeiro  8 , Raul Y Sanchez David, Lise Chauveau, Nolwenn Jouvenet, Martin Markowitz, Sylvie van der Werf, Olivier Schwartz, Frédéric Tangy, Nina Bhardwaj, Benjamin D Greenbaum, Anastassia V Komarova

Proc natl Acad Sci USA. 2022 Jan 25;119(4):e2116735119. doi: 10.1073/pnas.2116735119. CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Franziska K Geis, Yosef Sabo, Xiao Chen, Yinglu Li, Chao Lu, Stephen P Goff

Nat Chem Bio. 2022 Jun 2. doi: 10.1038/s41589-022-01060-0. Online ahead of print.  A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

Bhavesh Khatri, Ishika Pramanick, Sameer Kumar Malladi, Raju S Rajmani, Sahil Kumar, Pritha Ghosh, Nayanika Sengupta, R Rahisuddin, Narender Kumar, S Kumaran, Rajesh P Ringe, Raghavan Varadarajan, Somnath Dutta, Jayanta Chatterjee

Cell Rep. 2022 Apr 12;39(2):110690. doi: 10.1016/j.celrep.2022.110690. Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Jeffrey R Johnson, David C Crosby, Judd F Hultquist, Andrew P Kurland, Prithy Adhikary, Donna Li, John Marlett, Justine Swann, Ruth Hüttenhain, Erik Verschueren, Tasha L Johnson, Billy W Newton, Michael Shales, Viviana A Simon, Pedro Beltrao, Alan D Frankel, Alexander Marson, Jeffery S Cox, Oliver I Fregoso, John A T Young, Nevan J Krogan

Mol Cell. 2022 Mar 22;S1097-2765(22)00213-1. doi: 10.1016/j.molcel.2022.03.004. Online ahead of print. Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. William Garland, Iris Müller, Mengjun Wu, Manfred Schmid, Katsutoshi Imamura, Leonor Rib, Albin Sandelin, Kristian Helin, Torben Heick Jensen

Nature, 2022 Mar;603(7899):145-151. doi: 10.1038/s41586-022-04421-w. Epub 2022 Jan 19. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Jeremy Di Domizio, Muhammet F Gulen, Fanny Saidoune, Vivek V Thacker, Ahmad Yatim, Kunal Sharma, Théo Nass, Emmanuella Guenova, Martin Schaller, Curdin Conrad, Christine Goepfert, Laurence de Leval, Christophe von Garnier, Sabina Berezowska, Anaëlle Dubois, Michel Gilliet, Andrea Ablasser

Nat Microbiol, 2021 Sep;6(9):1211. doi: 10.1038/s41564-021-00960-6.  Author Correction: MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation. Gilberto Betancor, Jose M Jimenez-Guardeño, Steven Lynham, Robin Antrobus, Hataf Khan, Andrew Sobala, Matthew D J Dicks, Michael H Malim

Nature Aging, 2022, SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response. Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto & Eiji Hara

Embo J. 2021 Nov 15;40(22):e108234. doi: 10.15252/embj.2021108234. Epub 2021 Sep 29. DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis Mirjam A Beck, Heinz Fischer, Lisa M Grabner, Tamara Groffics, Mircea Winter, Simone Tangermann, Tina Meischel, Barbara Zaussinger-Haas, Patrick Wagner, Carina Fischer, Christina Folie, Julia Arand, Christian Schöfer, Bernard Ramsahoye, Sabine Lagger, Georg Machat, Gregor Eisenwort, Stephanie Schneider, Alexandra Podhornik, Michael Kothmayer, Ursula Reichart, Martin Glösmann, Ido Tamir, Michael Mildner, Raheleh Sheibani-Tezerji, Lukas Kenner, Peter Petzelbauer, Gerda Egger, Maria Sibilia, Andrea Ablasser, Christian Seiser

Viruses, volume 12, issue 13. Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein. Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen and Michaela Rumlová

Nat Commun. 2021 Nov 15;12(1):6602. doi: 10.1038/s41467-021-26910-8. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Ji-Seung Yoo, Michihito Sasaki, Steven X Cho, Yusuke Kasuga, Baohui Zhu, Ryota Ouda, Yasuko Orba, Paul de Figueiredo, Hirofumi Sawa, Koichi S Kobayashi

Nature 2021 Oct;598(7882):682-687. doi: 10.1038/s41586-021-03994-2. Epub 2021 Oct 20. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements Shang-Min Zhang, Wesley L Cai, Xiaoni Liu, Durga Thakral, Jiesi Luo, Lok Hei Chan, Meaghan K McGeary, Eric Song, Kim R M Blenman, Goran Micevic, Shlomit Jessel, Yangyi Zhang, Mingzhu Yin, Carmen J Booth, Lucia B Jilaveanu, William Damsky, Mario Sznol, Harriet M Kluger, Akiko Iwasaki, Marcus W Bosenberg, Qin Yan 

PLoS Pathog 2021 Aug 2;17(8):e1009775. doi: 10.1371/journal.ppat.1009775. eCollection 2021 Aug. Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig Sinn, Olga Ruda Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel

Cell 2021 Sep 15;S0092-8674(21)01046-1. doi: 10.1016/j.cell.2021.08.035. Online ahead of print. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion Guilherme Pedreira de Freitas Nader, Sonia Agüera-Gonzalez, Fiona Routet , Matthieu Gratia , Mathieu Maurin, Valeria Cancila , Clotilde Cadart, Andrea Palamidessi, Rodrigo Nalio Ramos, Mabel San Roman, Matteo Gentili, Ayako Yamada, Alice Williart, Catalina Lodillinsky, Emilie Lagoutte, Catherine Villard, Jean-Louis Viovy, Claudio Tripodo, Jérôme Galon, Giorgio Scita, Nicolas Manel, Philippe Chavrier, Matthieu Piel

Cell Rep. 2021 Jan 5;34(1):108586.  doi: 10.1016/j.celrep.2020.108586.  A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA. Hong Sun, Yu Huang, Shan Mei, Fengwen Xu, Xiaoman Liu, Fei Zhao, Lijuan Yin, Di Zhang, Liang Wei, Chao Wu, Shichao Ma, Jianwei Wang, Shan Cen, Chen Liang, Siqi Hu, Fei Guo

Science. 2021 Jul 16;373(6552):eabe4832.  doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Senolytics reduce coronavirus-related mortality in old mice. Christina D Camell, Matthew J Yousefzadeh, Yi Zhu, Larissa G P Langhi Prata, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Pengcheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christina L Inman, Kurt O Johnson, Stephanie H Cholensky, Timothy W Carlson, Nathan K LeBrasseur, Sundeep Khosla, M Gerard O'Sullivan, David B Allison, Stephen C Jameson, Alexander Meves, Ming Li  11 , Y S Prakash, Sergio E Chiarella, Sara E Hamilton, Tamara Tchkonia, Laura J Niedernhofer, James L Kirkland, Paul D Robbins.

Nature 2021 Jul;595(7866):309-314. doi: 10.1038/s41586-021-03520-4. Epub 2021 May 5.  Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Gabriel K Griffin, Jingyi Wu, Arvin Iracheta-Vellve, James C Patti, Jeffrey Hsu, Thomas Davis, Deborah Dele-Oni, Peter P Du, Aya G Halawi, Jeffrey J Ishizuka, Sarah Y Kim, Susan Klaeger, Nelson H Knudsen, Brian C Miller, Tung H Nguyen, Kira E Olander, Malvina Papanastasiou, Suzanna Rachimi, Emily J Robitschek, Emily M Schneider, Mitchell D Yeary, Margaret D Zimmer, Jacob D Jaffe, Steven A Carr, John G Doench, W Nicholas Haining, Kathleen B Yates, Robert T Manguso, Bradley E Bernstein

Nat Immunol. 2021 Jul;22(7):820-828. doi: 10.1038/s41590-021-00942-0. Epub 2021 May 11. PMID: 33976430 DOI: 10.1038/s41590-021-00942-0. RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells. Taisho Yamada, Seiichi Sato, Yuki Sotoyama, Yasuko Orba, Hirofumi Sawa, Hajime Yamauchi, Michihito Sasaki, Akinori Takaoka

Cell Host Microbe 2021 May 12;29(5):792-805.e6. doi: 10.1016/j.chom.2021.03.001. Epub 2021 Apr 2.

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

Liane Dupont, Stuart Bloor, James C Williamson, Sergio Martínez Cuesta, Raven Shah, Ana Teixeira-Silva, Adi Naamati, Edward J D Greenwood, Stefan G Sarafianos, Nicholas J Matheson, Paul J Lehner

Nat Microbiol. 2021 Apr;6(4):435-444. doi: 10.1038/s41564-021-00868-1. Epub 2021 Mar 1. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Stephanie V Rebensburg, Guochao Wei, Ross C Larue, Jared Lindenberger, Ashwanth C Francis, Arun S Annamalai, James Morrison, Nikoloz Shkriabai, Szu-Wei Huang, Vineet KewalRamani, Eric M Poeschla, Gregory B Melikyan, Mamuka Kvaratskhelia

Nat MicroBiol. 2021 Apr;6(4):467-478. doi: 10.1038/s41564-021-00884-1. Epub 2021 Mar 16. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. GuanQun Liu, Jung-Hyun Lee, Zachary M Parker, Dhiraj Acharya, Jessica J Chiang, Michiel van Gent, William Riedl, Meredith E Davis-Gardner, Effi Wies, Cindy Chiang, Michaela U Gack

Cell. 2021 Feb 18;184(4):1032-1046.e18. doi: 10.1016/j.cell.2021.01.025. Epub 2021 Feb 10. Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Vojtech Zila, Erica Margiotta, Beata Turoňová, Thorsten G Müller, Christian E Zimmerli, Simone Mattei, Matteo Allegretti, Kathleen Börner, Jona Rada, Barbara Müller, Marina Lusic, Hans-Georg Kräusslich, Martin Beck

Science. 2021 Mar 19;371(6535):eabc5386. doi: 10.1126/science.abc5386. Epub 2021 Feb 4. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Tuo Li, Tuozhi Huang, Mingjian Du, Xiang Chen, Fenghe Du, Junyao Ren, Zhijian J Chen

Cell Host Microb. 2021 Mar 10;29(3):489-502.e8. doi: 10.1016/j.chom.2021.01.015. Epub 2021 Jan 29. Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. Jing-Wen Lin, Chao Tang, Han-Cheng Wei, Baowen Du, Chuan Chen, Minjin Wang, Yongzhao Zhou, Ming-Xia Yu, Lu Cheng, Suvi Kuivanen, Natacha S Ogando, Lev Levanov, Yuancun Zhao, Chang-Ling Li, Ran Zhou, Zhidan Li, Yiming Zhang, Ke Sun, Chengdi Wang, Li Chen, Xia Xiao, Xiuran Zheng, Sha-Sha Chen, Zhen Zhou, Ruirui Yang, Dan Zhang, Mengying Xu, Junwei Song, Danrui Wang, Yupeng Li, ShiKun Lei, Wanqin Zeng, Qingxin Yang, Ping He, Yaoyao Zhang, Lifang Zhou, Ling Cao, Feng Luo, Huayi Liu, Liping Wang, Fei Ye, Ming Zhang, Mengjiao Li, Wei Fan, Xinqiong Li, Kaiju Li, Bowen Ke, Jiannan Xu, Huiping Yang, Shusen He, Ming Pan, Yichen Yan, Yi Zha, Lingyu Jiang, Changxiu Yu, Yingfen Liu, Zhiyong Xu, Qingfeng Li, Yongmei Jiang, Jiufeng Sun, Wei Hong, Hongping Wei, Guangwen Lu, Olli Vapalahti, Yunzi Luo, Yuquan Wei, Thomas Connor, Wenjie Tan, Eric J Snijder, Teemu Smura, Weimin Li, Jia Geng, Binwu Ying, Lu Chen.

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