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Selected publications from members of the Jolly Lab.

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Mesner D, Reuschl A-K, Whelan MVX, Bronzovich T, Haider T, Thorne LG, Ragazzini R, Bonfanti P, Towers GJ, Jolly C (2023). SARS-CoV-2 evolution influences GBP and IFITM sensitivity. Proc Natl Acad Sci USA. 2023 Jan 31;120(5): e2212577120.

Reuschl A-K, Mesner D, Shivkumar M ... Noursadeghi M, Maini MK, Jolly C (2022). HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells. Cell Rep 2022 Apr 12;39(2): 110650.

Thorne LG, Bouhaddou M, Reuschl A-K ... Jolly C, Towers GJ, Krogan NJ (2021). Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature 2021 Dec 23.

Haider T, Snetkov X, Jolly C (2021) HIV envelope tail truncation confers resistance to SERINC5 restriction. Proc Natl Acad Sci U S A. 2021 May 25;118(21): e2101450118.

Schmidt NM, Wing PAC, Diniz MO, Pallett LJ, Swadling L ... Jolly C, Jury EC, McKeating JA, Maini MK (2021). Targeting human Acyl-CoA: cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nat Commun. 2021 May 14;12(1): 2814.

O'Nions J, Muir L, Zheng J ... Gupta R, Khwaja A, Jolly C, McCoy LE (2020). SARS-CoV-2 antibody responses in patients with aggressive haematological malignancies. MedRxiv.

Mesner D, Hotter D, Kirchhoff F, Jolly C (2020). Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13): 7382-7391.

Titanji BK, Pillay D, and Jolly C (2017). Combination antiretroviral therapy and cell-cell spread of wild-type and drug-resistant human immunodeficiency virusu-1. Journal of General Virology 98: 821-834.

Len AC, Starling S, Shivkumar M and Jolly C (2017). HIV-1 activates signaling independently of antigen to drive viral spread. Cell Reports 18: 1062-1074.

Starling S, Jolly C (2016). LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse. J Virol. 2016 Nov 1;90(21): 9841-9854.

Zhang C, Zhou S, Groppelli E, Pellegrino P, Williams I, Borrow P, Chain B and Jolly C (2015). Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection. PloS Computational Biology. 11:e1004179.

Groppelli E, Starling S and Jolly C (2015). Contact-induced mitochondria polarization supports HIV-1 virological synapse formation. Journal of Virology. 89: 14-24.

Groppelli E, Len A, Granger L, and Jolly C (2014). Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions. PLoS Pathogens 10:e1004518.

McCoy L, Groppelli E, Blanchetot C ... Jolly C (2014). Neutralisation of HIV-1 cell-cell spread by human and llama antibodies Retrovirology 11:83.

Titanji B, Aasa-Chapman M, Pillay D and Jolly C (2013). Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells. Retrovirology 10: 161.

Wei B, Han L, Abbink T ... Jolly C., Wang H. and Rudd C (2013). Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10:101.

Jolly C, Welsch S, Michor S and Sattentau Q (2011). The regulated secretory pathway in CD4+ T cells contributes to Human Immunodeficiency Virus type-1 cell-to-cell spread at the virological synapse. PLoS Pathogens 7, e10022226.

Zhou L, Sokolskaja E, Jolly C, James W, Cowley S and Fassati A (2011). Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. PLoS Pathogens 7, e1002194.

Jolly C (2011). Cell-to-Cell transmission of retroviruses: Innate immunity and interferon induced restriction factors. Virology 411: 251-259.

Jolly C (2011). T cell polarization at the Virological Synapse. Viruses 2: 1261-1278.

Jolly C, Booth N and Neil S (2010). Cell-cell spread of human immunodeficiency virus type-1 overcomes tetherin/BST-2 mediated restriction in T cells. Journal of Virology 84: 12185-99.

Gonzalez N, Bermejo M, Calinge E, Jolly C, et al (2010). SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse. Journal of Virology 84: 4341-51.

Martin N, Welsch S, Jolly C, Briggs J, Vaux D and Sattentau Q (2010). Virological synapse-mediated spread of Human Immunodeficiency Virus Type-1 between T cells is sensitive to entry inhibition. Journal of Virology 84: 3516-27.

Sowinski S, Jolly C, Berninghausen O, Purboo M, Chauveau A, et al (2008). Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nature Cell Biology 10: 211-9.

Jolly C, and Sattentau QJ (2007). Regulated secretion from CD4+ T cells. Trends in Immunology 28: 474-81.

Jolly C, Mitar I, and Sattentau Q (2007). Adhesion molecule interactions facilitate human immunodeficiency type-1 induced virological synapse formation between T cells. Journal of Virology 81: 13916-21.

Jolly C and Sattentau Q (2007). Human immunodeficiency type-1 assembly, budding and cell-cell spread in T cells takes place in tetraspanin-enriched plasma membrane domains. Journal of Virology 81: 7873-84.

Jolly C, Mitar I, and Sattentau Q (2007). Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and cell-cell spread of Human Immunodeficiency Virus Type-1. Journal of Virology 81:5547-60.

Jolly C and Sattentau Q (2005). Human Immunodeficiency Virus type-1 virological synapse formation in T cells requires lipid raft integrity. Journal of Virology 79: 12088-94.

Jolly C, Kashefi K, Hollinshead M, and Sattentau Q (2004). HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. Journal of Experimental Medicine 199: 283-93.

Highlights in Medical Sciences

UCL Cancer Institute awarded Athena SWAN Gold
Athena Swan Gold Award

Award

UCL Cancer Institute awarded Athena SWAN Gold

The UCL Cancer Institute has been awarded Athena SWAN Gold in recognition of its sustained commitment to advancing gender equality in higher education and research.

20 May 2025

New Dean of Medical Sciences appointed
Professor Emma Morris

Announcement

New Dean of Medical Sciences appointed

Internationally recognised clinician scientist, Professor Emma Morris, will take up the role of Dean of UCL's Faculty of Medical Sciences in August 2025.

28 February 2025

Lung cancer test better predicts survival in early stages of disease
Cancer Cells Dividing

Research breakthrough

Lung cancer test better predicts survival in early stages of disease

A new test developed by UCL Cancer Institute and the Francis Crick Institute can better predict lung cancer survival at diagnosis.

09 January 2025

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