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David Moore is undertaking research within the field of molecular diagnostics, specifically the large scale retrospective analysis of next generation sequencing methods for somatic variant analysis.
Preinvasive neoplastic disease in lung adenocarcinoma and the biological switching from an in situ to invasive phenotype in this disease.
Tumours of the lung in the neuroendocrine spectrum and how genomic alterations correlate with phenotypic differences across this spectrum.
Characterising the immune infiltrate within primary non small cell lung cancer and metastatic disease sampled at post mortem.
Research Projects
I am actively involved in the TRACERx non small cell lung cancer project and the associated PEACE study at UCL.
Leading projects evaluating NGS technologies and their use in routine molecular diagnostics through my work in the Sarah Cannon Molecular Diagnostics Laboratory.
Pathology risks being left behind as conceptual and technological advances accelerate
Although there are still forms of cancer for which the promise of molecular diagnostics and personalized medicine is not yet a reality, there is no doubt that the era of genomic medicine is upon us.
Jamal-Hanjani M, Wilson GA, McGranahan N ... Moore DA, et al. Tracking the Evolution of Non-Small-Cell Lung Cancer. N Engl J Med. 2017 Jun 1;376(22): 2109-2121.
