Lab members

Investigates the role of CD4+ T cells in anti-tumour immunity, with a focus on how the differentiation of cytotoxic CD4+ T cells is regulated on an epigenetic and transcriptional level in tumours.

Studies the immune landscape in poorly-infiltrated mouse models following Treg depletion and inoculation with a cancer vaccine. Also interested in exploring the potential mechanisms underlying tumour resistance to the combinatorial therapy.

Studies the immune landscape in poorly-infiltrated mouse models following Treg depletion and inoculation with a cancer vaccine. Also interested in exploring the potential mechanisms underlying tumour resistance to the combinatorial therapy.

Develops a loss-of-function pipeline with in vitro and in vivo models of tumour reactivity using CRISPR/Cas9 methodology in order to identify targetable pathways that enhance T cell activation in the context of non-small cell lung cancer (NSCLC). Other responsibilities include assisting with the engineering of bispecific antibodies against Fcγ receptors, managing the lab and social media. Follow on LinkedIn.

Explores how changes in T cell function can contribute to the progression of pre-cancerous conditions such as smouldering multiple myeloma. Investigates T cell responses at the single cell level by analysing RNA-seq, TCR-seq and flow/mass cytometry data using machine learning and computational statistics. Follow on X.

Develops the tumour fragment platform as an ex vivo technique and investigates its ability to recapitulate the complexity of tumour architecture and the microenvironment. Also interested in the immunotherapeutic response of the tumour fragment platform to fs-indel derived neoantigens escaping from the nonsense-mediated decay (NMD) pathway. Follow on LinkedIn.

Established and runs a patient-derived immune xenograft (PDiX) core as part of the Cancer Research UK City of London (CRUK CoL) Centre. This includes writing SOPs, establishing tissue biobanks and collaborating with other research groups. Other responsibilities including managing lab admin, social media, and members of the group. Follow on LinkedIn.

Handles the processing, storage and retrieval of all clinical samples for immunological analysis ensuring compliance with the Human Tissue Act and maintaining Good Clinical Lab Practice. Other responsibilities include managing lab social media. Follow on LinkedIn.

Responsible for the development and implementation of the Biotherapeutics pipeline, with a heavy focus on the design, development and purification of Bi- and Tri-specific antibodies. Follow on LinkedIn.

Provides a service for multiplex immunolabelling to pharmaceutical companies and clinical trials. Focuses on tissue-based arrays and image analysis.