Sarcoma Trials

A list of our early phase sarcoma trials which are open to recruitment at University College London Hospitals.

Additional early phase clinical trials recruiting Sarcoma cohorts may be found in the Advanced Solid Tumour Trials Portfolio page.

FaR-RMS

An overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma

IRAS Number:254931
Principal Investigator:Dr. Maria Michelagnoli
Drug Class/ Treatment:Trial of various Immunotherapy, Targeted Therapy Agents and Radiotherapy.
Patient Population:

Newly Diagnosed and Relapsed Rhabdomyosarcoma (RMS)

Age >12 months and ≤25 years

Trial Hosted By - UCLH Cancer Clinical Trials Unit (CCTU)

SPEARHEAD-1

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR™ T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

IRAS Number:265659
Principal Investigator:Prof. Sandra Strauss
Drug Class/ Treatment:ADP-A2M4 SPEAR™ T Cells - Genetically Modified T-Cells targeting MAGEA4 (Melanoma-Associated Antigen 4)
Patient Population:

Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Age 16 - 75

Trial Hosted By - UCLH Cancer Clinical Trials Unit (CCTU)

LIGHTBEAM-U01 (MK-9999-01a Sub Study)

LIGHTBEAM-U01 Sub study 01A: A Phase 1/2 Sub-study to Evaluate the  Safety and Efficacy of Zilovertamab Vedotin in Paediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumours

IRAS Number:1008911
Pincipal Investigator:Dr Rachel Windsor
Drug Class/ Treatment:Zilovertamab Vedotin - Antibody-Drug Conjugate
Patient Population:

Paediatric Patients (1 - <18 Years):

  • B-ALL
  • DLBCL/Burkitt Lymphoma
  • Neuroblastoma

Paediatric and Young Adult Patients (Birth - 25 Years):

  • Ewing Sarcoma
Trial Hosted By - UCLH Cancer Clinical Trials Unit (CCTU)

Principal Investigator(s)

Professor Sandra Strauss
Professor Sandra Strauss

Senior Clinical Lecturer & Honorary Consultant Medical Oncologist