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Breast Trials

A list of our early phase breast cancer trials which are open to recruitment at University College London Hospitals

ELEVATE A Phase 1b/2, Open-label Umbrella Study to Evaluate Safety and Efficacy of Elacestrant in Various Combinations in Patients with Metastatic Breast Cancer (ELEVATE)
IRAS Number:	1007543
Principal Investigator	Dr Rebecca Roylance
Drug Class/ Treatment:	Elacestrant (Estrogen Receptor Antangonist) + Various Combination
Patient Population:	ER+, HER2– Breast Cancer
Trial Hosted By - NIHR UCLH Clinical Research Facility (CRF)

ELECTRA (ELA-0121) A Phase 2 Study of Magrolimab Combination Therapy in Patients With Unresectable, Locally Advanced or Metastatic
IRAS Number:	1005373
Principal Investigator	Dr Elisavet Papadimitraki
Drug Class/ Treatment:	Elacestrant (Oral selective ER degrader)
Patient Population:	Women and men with brain metastasis from estrogen receptor positive, her-2 negative breast cancer
Trial Hosted By - NIHR UCLH Clinical Research Facility (CRF)

PAveMent Phase 1b study of Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer
IRAS Number:	245336
Principal Investigator:	Dr Rebecca Roylance
Drug Class/ Treatment:	Palbociclib (CDK4 and CDK6 Inhibitor) + Avelumab (PD-L1 Monoclonal Antibody)
Patient Population:	AR+ Triple Negative Breast Cancer
Trial Hosted By - NIHR UCLH Clinical Research Facility (CRF)

Principal Investigator(s)

Dr Elisavet (Elsa) Papadimitraki

Consultant Medical Oncologist

Dr Rebecca Roylance

Clinical Medical Oncologist

Highlights in Medical Sciences

Millions could benefit from faster prostate cancer scan

Research

Millions could benefit from faster prostate cancer scan

Results of the PRIME trial involving UCL Medical Sciences researchers have found that a quicker, cheaper MRI scan was just as accurate at diagnosing prostate cancer as the current 30-40 minute scan.

UCL Cancer Institute awarded Athena SWAN Gold

Award

UCL Cancer Institute awarded Athena SWAN Gold

The UCL Cancer Institute has been awarded Athena SWAN Gold in recognition of its sustained commitment to advancing gender equality in higher education and research.

New Dean of Medical Sciences appointed

Announcement

New Dean of Medical Sciences appointed

Internationally recognised clinician scientist, Professor Emma Morris, will take up the role of Dean of UCL's Faculty of Medical Sciences in August 2025.